Association of dietary acid load with serum bicarbonate in chronic kidney disease (CKD) patients

Autor: Gabriela Cristina Arces de Souza, Larissa Rodrigues Neto Angéloco, Lynda A. Frassetto, Elen Almeida Romão, Paula Garcia Chiarello
Rok vydání: 2020
Předmět:
Zdroj: European Journal of Clinical Nutrition. 74:69-75
ISSN: 1476-5640
0954-3007
DOI: 10.1038/s41430-020-0689-1
Popis: BACKGROUND/OBJECTIVES Diet can affect the acid-base status depending on the balance between the intake of acid-inducing foods and base-inducing foods. The purpose of this study was to estimate the dietary acid load and evaluate its association with serum bicarbonate in patients with stages 3 and 4 chronic kidney disease. SUBJECTS/METHODS One hundred adults (aged ≥ 20 years) with chronic kidney disease (CKD) stages 3 and 4 were enrolled in a cross-sectional study. A food diary was used to estimate the animal and plant protein intakes, which were used in the potential renal acid load (PRAL) formula described by Remer and Manz. PRAL was divided into quartiles. Regression models unadjusted and adjusted for age, gender, body mass index, diabetes, systolic and diastolic blood pressure, creatinine clearance were performed using the stepwise regression method. RESULTS The median level (25th, 75th percentiles) of PRAL was 8.3 mEq/day (1.6, 15.6). The highest quartile of PRAL had a higher consumption of animal protein (77.8 ± 10.9%) and a reduced consumption of plant protein (22.2 ± 10.9%), compared to the lowest quartile (59.5 ± 18.6% animal protein, 40.5 ± 18.6% plant protein), p for trend
Databáze: OpenAIRE
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