Inhibition of Experimental Tinnitus With High Frequency Stimulation of the Rat Medial Geniculate Body

Autor: Robert J. Stokroos, A. Miranda L. Janssen, Milaine Roet, Yasin Temel, Ali Jahanshahi, Gusta van Zwieten, Marcus L.F. Janssen, Jasper V. Smit
Přispěvatelé: RS: MHeNs - R3 - Neuroscience, Promovendi MHN, KNO, MUMC+: MA Keel Neus Oorheelkunde (9), MUMC+: HZC Med Staf Spec Klinische Neurofys (9), Klinische Neurowetenschappen, Neurochirurgie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA AIOS Keel Neus Oorheelkunde (9), FHML Methodologie & Statistiek, MUMC+: MA Med Staf Spec Neurochirurgie (9)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Startle response
Tinnitus/physiopathology
medial geniculate body
Deep Brain Stimulation
Stimulation
Audiology
Evoked Potentials
Auditory
Brain Stem/physiology
ACTIVATION
Rats
Sprague-Dawley
Tinnitus
0302 clinical medicine
Deep brain stimulation
preclinical
Medicine
Evoked Potentials
Auditory
Brain Stem/physiology
Prepulse inhibition
medicine.diagnostic_test
SUBTHALAMIC NUCLEUS
Geniculate Bodies
General Medicine
Medial geniculate body
Neuromodulation (medicine)
BEHAVIORAL EVIDENCE
Neurology
ANIMAL-MODELS
Evoked Potentials
Auditory/physiology
neuromodulation
Evoked Potentials
Auditory
medicine.symptom
NEURONAL-ACTIVITY
DEEP BRAIN-STIMULATION
medicine.medical_specialty
Thalamus
Clinical Neurology
Geniculate Bodies/physiopathology
03 medical and health sciences
Deep Brain Stimulation/methods
Journal Article
otorhinolaryngologic diseases
Evoked Potentials
Auditory
Brain Stem
Animals
tinnitus
MODULATION
Auditory/physiology
SUPPRESSION
Animal
business.industry
Hyperacusis
ELECTRICAL-STIMULATION
HYPERACUSIS
Rats
Editor's Choice
Disease Models
Animal
Acoustic Stimulation/adverse effects
Anesthesiology and Pain Medicine
Basic Research
Acoustic Stimulation
Disease Models
Sprague-Dawley
Neurology (clinical)
Brain Stimulation
business
030217 neurology & neurosurgery
Zdroj: Neuromodulation
Neuromodulation, 22(4), 416-424. Wiley
Neuromodulation : journal of the International Neuromodulation Society, 22(4), 416. Wiley-Blackwell Publishing Ltd
ISSN: 1525-1403
1094-7159
Popis: Background Neuromodulation is a promising treatment modality for tinnitus, especially in chronic and severe cases. The auditory thalamus plays a key role in the pathophysiology of tinnitus, as it integrates and processes auditory and limbic information. Objective The effect of high frequency stimulation and low frequency stimulation of the medial geniculate bodies on tinnitus in a noise-induced tinnitus rat model is assessed. Materials and methods Presence of tinnitus was verified using the gap-induced prepulse inhibition of the acoustic startle response paradigm. Hearing thresholds were determined before and after noise trauma with auditory brainstem responses. Anxiety-related side-effects were evaluated in the elevated zero maze and open field. Results Results show tinnitus development after noise exposure and preserved hearing thresholds of the ear that was protected from noise trauma. We found that high frequency stimulation of the medial geniculate bodies suppressed tinnitus. This effect maintained directly after stimulation when the stimulator was turned off. Low frequency stimulation did not have any effects on the gap:no-gap ratio of the acoustic startle response. Conclusion High frequency stimulation of the MGB has a direct and residual suppressing effect on tinnitus in this animal model. Low frequency stimulation of the MGB did not inhibit tinnitus.
Databáze: OpenAIRE
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