Association of the Optic Disc Structure With the Use of Antihypertensive Medications
| Autor: | Theofanis Pappas, Fotis Topouzis, Archimidis Koskosas, M. Roy Wilson, Fei Yu, Gordon Gong, Eleftherios Anastasopoulos, Alon Harris, Panayiota Founti, Nisha Kheradiya, Christian Paul Jonescu-Cuypers, Anne L. Coleman |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Adrenergic beta-Antagonists Optic Disk Glaucoma Angiotensin-Converting Enzyme Inhibitors Blood Pressure Diuretics/therapeutic use Angiotensin Receptor Antagonists Drug Therapy Calcium Channel Blockers/therapeutic use Ophthalmology Humans Medicine Diuretics Tomography Antihypertensive Agents Optic disc structure Antihypertensive Agents/therapeutic use Hypertension/drug therapy/physiopathology business.industry Blood Pressure Determination Calcium Channel Blockers Adrenergic beta-Antagonists/therapeutic use medicine.disease Angiotensin Receptor Antagonists/therapeutic use eye diseases ddc:616.8 Angiotensin-Converting Enzyme Inhibitors/therapeutic use Cross-Sectional Studies Blood pressure Hypertension Combination Drug Therapy Combination Blood Pressure/drug effects/physiology Female business Optic Disk/pathology |
| Zdroj: | Journal of Glaucoma, Vol. 22, No 7 (2013) pp. 526-31 |
| ISSN: | 1057-0829 |
| DOI: | 10.1097/ijg.0b013e31824d1e12 |
| Popis: | To investigate the association of antihypertensive medications with optic disc structure by blood pressure (BP) level, in nonglaucoma subjects.Cross-sectional, population-based study.A subset of Thessaloniki Eye Study participants was included in this study. Subjects were interviewed for medical history and underwent extensive ophthalmic examination, BP measurement, and optic disc imaging with the Heidelberg retinal tomograph. Subjects treated for hypertension were grouped in the following groups: (1) angiotensin-converting enzyme inhibitors and/or angiotensin-receptor blockers; (2) beta blockers and/or calcium-channel blockers; (3) diuretics alone or combined with others; and (4) other combinations. Cup size and cup-to-disc (C/D) ratio in the above groups were compared with the untreated group, using regression models. Analyses were rerun for subjects with systolic BP (SBP)140 mm Hg, SBP≥140 mm Hg, diastolic BP (DBP)90 mm Hg, and DBP≥90 mm Hg.Among 232 subjects, 131 were receiving antihypertensive medications. In subjects with DBP90 mm Hg, all medications groups were associated with larger cup size and higher C/D ratio compared with the untreated group. Results were similar in subjects with SBP140 mm Hg, with the exception of the beta blockers and/or calcium-channel blockers group. None of the medications groups were associated with the Heidelberg retinal tomograph parameters in those with DBP≥90 mm Hg or SBP≥140 mm Hg.All classes of antihypertensive medications were associated with larger cup size and higher C/D ratio in subjects with either DBP90 mm Hg or SBP140 mm Hg. These results suggest that there is no specific medication-related effect on optic disc structure, and the associations found are mediated through the hypotensive effect of antihypertensive medications. |
| Databáze: | OpenAIRE |
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