Vaccination of Sheep with Bovine Viral Diarrhea Vaccines Does Not Protect against Fetal Infection after Challenge of Pregnant Ewes with Border Disease Virus
| Autor: | Mickael Combes, Hervé Cassard, Angélique Teillaud, Gilles Meyer, Marie-Anne Bethune, Celine Pouget |
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| Přispěvatelé: | Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groupement Vétérinaire Saint Léonard, Fédération des Organismes de Défense Sanitaire de l'Aveyron (FODSA), UCS - UPRA Calédonie Sélection (UCS-UPRA), This research was funded by the French Regional (Occitanie) Federation of 'groupements de defense sanitaire' and the 'Fédération des Organismes de Défense Sanitaire de l’Aveyron' which are French public breeders’ associations for health protection. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
sheep
040301 veterinary sciences medicine.medical_treatment [SDV]Life Sciences [q-bio] animal diseases viruses Immunology Bovine Viral Diarrhea Virus Article Virus 0403 veterinary science Border disease virus 03 medical and health sciences Drug Discovery Medicine Pharmacology (medical) Border Disease Virus 030304 developmental biology 2. Zero hunger Pharmacology 0303 health sciences Fetus Leukopenia biology business.industry Border Disease virus diseases Immunosuppression 04 agricultural and veterinary sciences vaccination protection Virology 3. Good health Vaccination fetus Infectious Diseases 13. Climate action biology.protein Antibody medicine.symptom business |
| Zdroj: | Vaccines, Vol 9, Iss 805, p 805 (2021) Vaccines Vaccines, MDPI, 2021, 9 (8), pp.805. ⟨10.3390/vaccines9080805⟩ Volume 9 Issue 8 |
| ISSN: | 2076-393X |
| DOI: | 10.3390/vaccines9080805⟩ |
| Popis: | International audience; Border Disease (BD) is a major sheep disease characterized by immunosuppression, congenital disorders, abortion, and birth of lambs persistently infected (PI) by Border Disease Virus (BDV). Control measures are based on the elimination of PI lambs, biosecurity, and frequent vaccination which aims to prevent fetal infection and birth of PI. As there are no vaccines against BDV, farmers use vaccines directed against the related Bovine Viral Diarrhea Virus (BVDV). To date, there is no published evidence of cross-effectiveness of BVDV vaccination against BDV infection in sheep. We tested three commonly used BVDV vaccines, at half the dose used in cattle, for their efficacy of protection against a BDV challenge of ewes at 52 days of gestation. Vaccination limits the duration of virus-induced leukopenia after challenge, suggesting partial protection in transient infection. Despite the presence of BDV neutralizing antibodies in vaccinated ewes on the day of the challenge, fetuses of vaccinated and unvaccinated sheep were, two months after, highly positive for BDV RNA loads and seronegative for antibodies. Therefore, BVDV vaccination at half dose was not sufficient to prevent ovine fetal infection by BDV in a severe challenge model and can only be reconsidered as a complementary mean in BD control. |
| Databáze: | OpenAIRE |
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