Evaluation of solvent/detergent treated plasma in the management of patients with hereditary and acquired coagulation disorders
| Autor: | D. Blickstein, Uriel Martinowitz, O. Epstein, N. Kornbrot, Benjamin Brenner, Aida Inbal |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Detergents Gastroenterology Virus Plasma Liver disease chemistry.chemical_compound Internal medicine Coagulopathy Humans Medicine Solvent detergent plasma Coagulation Disorder Aged Factor VII business.industry Hematology General Medicine Blood Coagulation Disorders Middle Aged medicine.disease Pharmacokinetic analysis Surgery chemistry Coagulation Solvents Female business |
| Zdroj: | Blood Coagulation & Fibrinolysis. 4:599-604 |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/00001721-199308000-00011 |
| Popis: | Haemostatic efficacy and pharmacokinetic analysis of solvent/detergent (S/D) treated, virus inactivated plasma (OctaplasTM, Germany) was evaluated in eight patients with hereditary factor VII, X and XI deficiency and in three patients with acquired coagulation disorders due to liver disease. The patients received the S/D plasma for treatment of haemarthrosis, menorrhagia or before surgical procedures. In all the patients the S/D plasma was sufficient to prevent or stop bleeding. Side effects included urticaria (one patient) and moderate anaphylactoid reaction (one patient). No evidence of plasma-born viral infections was observed up to 12 months after the treatment (95% confidence limits 0–22%). Calculated mean half-life of coagulation factors VII, X and XI was 4.36 h, 49.21 h and 44.5 h, respectively, similar to that observed with fresh-frozen plasma. Because of retained coagulation factor integrity and improved viral safety, S/D plasma could be considered a superior alternative to standard fresh-frozen plasma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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