Synthesis and antinociceptive activity of pyrazolyl isoxazolines and pyrazolyl isoxazoles
| Autor: | P. T. Perumal, K. G. Lalitha, Kesavan Karthikeyan, T. Veenus Seelan |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Nitrile
Clinical Biochemistry Pharmaceutical Science Administration Oral Pyrazole Biochemistry Chemical synthesis chemistry.chemical_compound Mice Structure-Activity Relationship Drug Discovery Organic chemistry Animals Molecular Biology Maleimide Analgesics Organic Chemistry Biological activity Isoxazoles Cycloaddition Rats chemistry Phenylacetylene Cyclization 1 3-Dipolar cycloaddition Molecular Medicine Pyrazoles |
| Zdroj: | Bioorganicmedicinal chemistry letters. 19(13) |
| ISSN: | 1464-3405 |
| Popis: | Pyrazolyl isoxazolines and isoxazoles were synthesised in moderate to good yields using 1,3-dipolar cycloaddition of pyrazole derived nitrile oxide with various dipolarophiles such as N-substituted maleimide, diethylacetylene dicarboxylate and phenylacetylene. The synthesized compounds were evaluated for antinociceptive activities. The 3-pyrazolyl-4,5-dicarbethoxy isoxazoles (9a–c) exhibited the maximum antinociceptive activity. |
| Databáze: | OpenAIRE |
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