Bone metastases and skeletal-related events: incidence and prognosis according to histological subtype of lung cancer
| Autor: | Anke Bergmann, Larissy Machado da Silva, Luiz Cs Thuler, Gustavo Telles da Silva |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Skeletal related events Bone Neoplasms 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Cumulative incidence Lung cancer Survival analysis Aged Neoplasm Staging Retrospective Studies business.industry Incidence Incidence (epidemiology) Hazard ratio Retrospective cohort study Patient survival General Medicine Middle Aged Prognosis medicine.disease Combined Modality Therapy respiratory tract diseases 030104 developmental biology 030220 oncology & carcinogenesis Female Bone Diseases Neoplasm Grading business Brazil |
| Zdroj: | Future Oncology. 15:485-494 |
| ISSN: | 1744-8301 1479-6694 |
| DOI: | 10.2217/fon-2018-0613 |
| Popis: | Aim: Estimate the incidence of bone metastases (BM) and skeletal-related events according to the histological subtype of lung cancer and its impact on patient survival. Patients & methods: Retrospective cohort study was carried out with patients diagnosed with lung cancer. Cumulative incidence, Kaplan–Meier survival analysis and the risk of death were estimated. Results: In non-small-cell lung cancer (NSCLC), the cumulative incidence of BM during follow-up was 23.8% at 24 months; in small-cell lung cancer, it was 18.5%. The presence of BM in patients with NSCLC was associated with an increased risk of death (hazard ratio: 1.25; 95% CI: 1.04–1.49; p = 0.013). Conclusion: This study revealed a high incidence of BM and skeletal-related events. BM was associated with a poor prognosis in NSCLC patients. |
| Databáze: | OpenAIRE |
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