Drug-induced pneumonitis following the administration of laninamivir octanoate: The first two reported cases
| Autor: | Keiko Ohgino, Tomoko Betsuyaku, Kyuto Tanaka, Takunori Ogawa, Nao Omori, Koichi Sayama |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine Microbiology (medical) medicine.medical_specialty medicine.drug_class 030106 microbiology Neuraminidase Laninamivir octanoate Antiviral Agents Bronchoalveolar Lavage Guanidines Gastroenterology Viral Proteins Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Administration Inhalation Influenza Human medicine Humans Zanamivir Pharmacology (medical) Drug-induced pneumonitis 030212 general & internal medicine Adverse effect Glucocorticoids Lung Pyrans Pneumonitis medicine.diagnostic_test Neuraminidase inhibitor business.industry Pneumonia medicine.disease Respiration Artificial Laninamivir Treatment Outcome Infectious Diseases Bronchoalveolar lavage Influenza A virus Sialic Acids Female Tomography X-Ray Computed business |
| Zdroj: | Journal of Infection and Chemotherapy. 25:1043-1046 |
| ISSN: | 1341-321X |
| DOI: | 10.1016/j.jiac.2019.05.008 |
| Popis: | Laninamivir, a neuraminidase inhibitor (NAI), has been used for the treatment and prophylaxis of influenza A/B. To date, pneumonia has not been reported as an adverse effect of NAIs. Here, we report the first 2 cases of drug-induced pneumonitis after the administration of laninamivir octanoate (LO), a pro-drug of laninamivir. Case 1 reports a 20-year-old healthy woman presenting with LO-induced pneumonitis so severe that it was necessary for endotracheal intubation and administration of mechanical ventilator support. Steroids were used for the treatment of pneumonitis and rapid improvement was observed. Case 2 reports a 35-year-old healthy woman presenting with less severe LO-induced pneumonitis that improved without any treatment. In both cases, drug-induced lymphocyte stimulation tests (DLSTs) were positive. In the bronchoalveolar lavage (BAL) fluid, the proportion of eosinophils to lymphocytes was higher in Case 1. Conversely, the proportion of lymphocytes to eosinophils was higher in Case 2. Collectively, we determined 3 clinical issues: (1) LO could cause pneumonia; (2) BAL and DLST could be helpful in the diagnosis of LO-induced pneumonitis; and (3) LO-induced pneumonia could become severe, though steroids were effective in improving it. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect