Repeat hepatectomy for recurrent hepatocellular carcinoma: a local experience and a systematic review
| Autor: | Zhenyu Liu, Jiamei Yang, Cheng-Jun Sui, Bin Li, Yanming Zhou, Yunchang Tan, Zheng-Feng Yin |
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| Rok vydání: | 2010 |
| Předmět: |
Reoperation
Oncology medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment lcsh:Surgery Repeat hepatectomy lcsh:RC254-282 Surgical oncology Internal medicine medicine Carcinoma Hepatectomy Humans Survival rate Aged Neoplasm Staging Retrospective Studies business.industry Research Liver Neoplasms Follow up studies Retrospective cohort study lcsh:RD1-811 Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Recurrent Hepatocellular Carcinoma Survival Rate Treatment Outcome Female Surgery Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | World Journal of Surgical Oncology World Journal of Surgical Oncology, Vol 8, Iss 1, p 55 (2010) |
| ISSN: | 1477-7819 |
| DOI: | 10.1186/1477-7819-8-55 |
| Popis: | Background This study aimed to assess the efficacy and safety of repeat hepatectomy for recurrent hepatocellular carcinoma (HCC). Methods Thirty-seven patients who underwent a curative repeat hepatectomy in our hospital were retrospectively studied. An extensive database literature search was performed to obtain for all relevant studies. Results In our series, there were no perioperative deaths during repeat hepatectomy for recurrent HCC. Patients survival after repeat hepatectomy were similar to 429 patients undergoing initial hepatectomy. A computerized search of the Medline and PubMed databases found 29 retrospective studies providing relevant data in 1149 patients were included for appraisal and data extraction. After the repeat hepatectomy, postoperative morbidity ranged from 6.2% to 68.2% with a median per cohort of 23.5 per cent. There were 7 perioperative deaths (0.7 per cent of 993 for whom mortality data were provided). The overall median survival ranged from 21 to 61.5 months, with 1 -, 3 -, and 5-year survival of 69.0% to 100%, 21.0% to 87.0%, and 25.0% to 87.0%, respectively. Conclusions Repeat hepatectomy can be performed safely and is associated with long-term survival in a subset of patients with recurrent HCC. However, the findings have to be carefully interpreted due to the lower level of evidence. A randomized controlled study is needed to compare repeat hepatectomy and other modalities for recurrent HCC. |
| Databáze: | OpenAIRE |
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