Effect of oral nifedipine on ocular blood flow in patients with low tension glaucoma
| Autor: | Moshe Lazar, Almog Y, Meira Neudorfer, Orna Geyer, E Firsteter, Ada Kessler |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure genetic structures Nifedipine Retinal Artery Diastole Hemodynamics Administration Oral Cellular and Molecular Neuroscience Ophthalmic Artery Oral administration Internal medicine medicine Laser-Doppler Flowmetry Humans Prospective Studies Intraocular Pressure Aged business.industry Ciliary Body Blood flow Calcium Channel Blockers Sensory Systems eye diseases Low Tension Glaucoma Ophthalmology Blood pressure Anesthesia Cardiology Female sense organs business Glaucoma Open-Angle medicine.drug Research Article |
| Zdroj: | The British journal of ophthalmology. 80(12) |
| ISSN: | 0007-1161 |
| Popis: | AIM: To investigate the effect of oral nifedipine on ocular blood flow in patients with low tension glaucoma (LTG). METHODS: In this prospective study we examined the effects of 3 weeks of treatment with oral nifedipine 30 mg/day in 11 patients with LTG, by using colour Doppler ultrasound imaging to measure haemodynamic variables in the central retinal (CRA), short posterior ciliary (SPCA), and ophthalmic (OA) arteries. Intraocular pressure (IOP) and blood pressures were also evaluated. RESULTS: Nifedipine failed to alter IOP nor did it change peak systolic velocity, end diastolic velocity,or the resistance index in any of the three ocular vessels studied (p > 0.05). However systolic and diastolic systemic arterial blood pressure measurements varied significantly after nifedipine treatment compared with baseline (p < 0.05). CONCLUSION: Our study failed to demonstrate a significant effect of nifedipine on retrobulbar circulation of patients with LTG. |
| Databáze: | OpenAIRE |
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