Parent–progeny recognition as a function of MHC odortype identity
| Autor: | Kunio Yamazaki, Gary K. Beauchamp, E A Boyse, J Bard, M Curran |
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| Rok vydání: | 2000 |
| Předmět: |
Genetics
Pregnancy Multidisciplinary Behavior Animal Outbreeding depression Identity (social science) Biological Sciences Biology medicine.disease Major histocompatibility complex Major Histocompatibility Complex Mice Inbred C57BL Loss of heterozygosity Mice Animals Newborn Mate choice Odorants Immunology medicine biology.protein Animals Female Gene polymorphism Function (biology) |
| Zdroj: | Proceedings of the National Academy of Sciences. 97:10500-10502 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.180320997 |
| Popis: | The several linked polymorphic genes of the MHC, which has been proposed as a prime determinant of sensed genetic individuality within species, is known to operate in mice by olfactory recognition in aspects of reproductive behavior that concern mate selection, thereby favoring outbreeding and heterozygosity, and also concern the maintenance of pregnancy. A single base-change can alter an individual MHC odortype, and the potential range of combinatorial MHC-determined odortypes is clearly vast. Following our findings that newborn mice already express their MHC odortype (which is detectable at 9 days of gestational age), we sought to determine whether MHC is involved in behavioral aspects of early development, such as rearing. In the studies presented herein, we report the ability and proclivity of mothers to recognize and preferentially retrieve syngeneic (genetically identical) pups from other pups differing only for MHC. Reciprocally, we report the ability of pups to recognize their familial environment, regardless of whether they had been nursed by their biological mothers or by foster mothers. Early learning experiences of the MHC environment are apparently a key element in survival, assuring maternal protection and promoting outbreeding. |
| Databáze: | OpenAIRE |
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