Predictors of Positive Bone Metastasis in Newly Diagnosed Prostate Cancer Patients
Autor: | Hung-Lung Ke, Shu-Pin Huang, Yii-Her Chou, Chun-Nung Huang, Wen-Jeng Wu, Yen-Man Lu, Ching-Chia Li, Tsu-Ming Chien, Jiun-Hung Geng, Tsung-Yi Huang |
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Rok vydání: | 2016 |
Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Epidemiology 030232 urology & nephrology Urology Bone Neoplasms Technetium Tc 99m Medronate Logistic regression 03 medical and health sciences Prostate cancer 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine medicine Humans Tissue Distribution Survival rate Aged Aged 80 and over Univariate analysis business.industry Public Health Environmental and Occupational Health Prostatic Neoplasms Bone metastasis Middle Aged Prognosis medicine.disease Survival Rate Prostate-specific antigen 030220 oncology & carcinogenesis Predictive value of tests Neoplasm Grading Radiopharmaceuticals business Body mass index Follow-Up Studies |
Zdroj: | Asian Pacific Journal of Cancer Prevention. 17:1187-1191 |
ISSN: | 1513-7368 |
Popis: | Background: The prevalence of prostate cancer (PCa) has been increasing in recent years. Treatment strategies are largely based on the results of bone scan screening. Therefore, our aim was to investigate predictors of positive bone metastasis in newly diagnosed PCa patients. Materials and Methods: After extensive review, 336 consecutive patients newly diagnosed with PCa between April 2010 and November 2013 at our institution were enlisted in the study. Patients were divided into two groups according to bone scan results. Univariate analyses (Chi-square test for discrete variables and independent t-test for continuous variables) were applied to determine the potentially significant risk factors associated with distant bone metastasis. Binary logistic regression analyses were used to further investigate the influence of these factors on bone metastasis. Results: The patient mean age was 71.9 ± 8.6 years (range: 48 to 94 years). The mean prostate specific antigen (PSA) level and biopsy Gleason score were 260.2 ± 1107.8 ng/mL and 7.4 ± 1.5, respectively. The body mass index (BMI) for the series was 24.5 ± 3.4 kg/m2. Sixty-four patients (19.0%) had a positive bone scan result. Patients with positive bone scan results had a significantly lower BMI (23.3 ± 3.5 vs. 24.8 ± 3.3; p=0.003), a higher Gleason score (8.5 ± 1.1 vs. 7.1 ± 1.5; p < 0.001), and a higher PSA level (1071.3 ± 2337.1 vs. 69.4 ± 235.5; p < 0.001) than those without bone metastasis. Multivariate logistic regression analysis employing the above independent predictors demonstrated that a Gleason score of ≥7, clinical stage ≥T3, BMI ≤22 kg/m2, and an initial PSA level of ≥20 ng/mL were all independent predictors of bone metastasis. Conclusions: A bone scan might be necessary in newly diagnosed PCa patients with any of the following criteria: clinical stage T3 or higher, a Gleason score of 7 or higher, BMI equal to or less than 22, and a PSA level of 20 or higher. |
Databáze: | OpenAIRE |
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