Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility

Autor: Francesco Pallotti, Daniele Gianfrilli, F. Sciarra, Edoardo Franceschini, Federica Campolo, Andrea M. Isidori, Mary Anna Venneri, Donatella Paoli
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Circadian clock
Disease
Review
hormones regulation
Body Temperature
lcsh:Chemistry
0302 clinical medicine
Heart Rate
Homeostasis
clock genes
fertility
reproduction
spermatogenesis
lcsh:QH301-705.5
Spectroscopy
media_common
Melatonin
General Medicine
Computer Science Applications
Circadian Rhythm
CLOCK
Androgens
Female
Suprachiasmatic Nucleus
Infertility
media_common.quotation_subject
030209 endocrinology & metabolism
Fertility
Mice
Transgenic
Biology
Catalysis
Inorganic Chemistry
03 medical and health sciences
Sleep Disorders
Circadian Rhythm
Circadian Clocks
medicine
Animals
Humans
Circadian rhythm
Physical and Theoretical Chemistry
Molecular Biology
Glucocorticoids
Organic Chemistry
Estrogens
medicine.disease
Hormones
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Neuroscience
Gonadotropins
Hormone
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 3943, p 3943 (2020)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: Infertility represents a growing health problem in industrialized countries. Thus, a greater understanding of the molecular networks involved in this disease could be critical for the development of new therapies. A recent finding revealed that circadian rhythmicity disruption is one of the main causes of poor reproductive outcome. The circadian clock system beats circadian rhythms and modulates several physiological functions such as the sleep-wake cycle, body temperature, heart rate, and hormones secretion, all of which enable the body to function in response to a 24 h cycle. This intricated machinery is driven by specific genes, called “clock genes” that fine-tune body homeostasis. Stress of modern lifestyle can determine changes in hormone secretion, favoring the onset of infertility-related conditions that might reflect disfunctions within the hypothalamic–pituitary–gonadal axis. Consequently, the loss of rhythmicity in the suprachiasmatic nuclei might affect pulsatile sexual hormones release. Herein, we provide an overview of the recent findings, in both animal models and humans, about how fertility is influenced by circadian rhythm. In addition, we explore the complex interaction among hormones, fertility and the circadian clock. A deeper analysis of these interactions might lead to novel insights that could ameliorate the therapeutic management of infertility and related disorders.
Databáze: OpenAIRE
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