Comparison of sugammadex and neostigmine–atropine on intraocular pressure and postoperative effects
| Autor: | Kasım Tuzcu, Murat Karcioglu, Selim Turhanoglu, Volkan Hanci, Isil Davarci, Esra Ayhan Tuzcu, Ahmet Elbeyli, Sedat Hakimoğlu, Suzan Aydın, Hilal Kahraman |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Atropine Male Intraocular pressure medicine.medical_specialty Adolescent genetic structures Neuromuscular Junction Hemodynamics Sugammadex 03 medical and health sciences Young Adult 0302 clinical medicine 030202 anesthesiology Extubation Heart rate medicine Humans Postoperative Period Intraocular Pressure Aged Medicine(all) lcsh:R5-920 business.industry General Medicine Middle Aged Neostigmine Surgery Treatment Outcome Neuromuscular Agents Anesthesia Anesthetic 030221 ophthalmology & optometry Female lcsh:Medicine (General) Airway business medicine.drug gamma-Cyclodextrins |
| Zdroj: | Kaohsiung Journal of Medical Sciences, Vol 32, Iss 2, Pp 80-85 (2016) |
| ISSN: | 1607-551X |
| DOI: | 10.1016/j.kjms.2016.01.009 |
| Popis: | During surgery, changes in intraocular pressure (IOP) can be observed resulting from several factors, such as airway manipulations and drugs used. We aimed to investigate the effects of sugammadex and neostigmine on IOP, hemodynamic parameters, and complications after extubation. Our study comprised 60 patients, aged 18-65 years, with a risk status of the American Society of Anesthesiologists I-II who underwent arthroscopic surgery under general anesthesia. The patients were randomly assigned into two groups. At the end of the surgery, the neuromuscular block was reversed using neostigmine (50 mu g/kg) plus atropine (15 mu g/kg) in Group 1, and sugammadex (4 mg/kg) in Group 2. Neuromuscular blockade was monitored using acceleromyography and a train-of-four mode of stimulation. IOP was measured before induction and at 30 seconds, 2 minutes, and 10 minutes after extubation. A Tono-Pen XL applanation tonometer was used to measure IOP. This showed that elevation in IOP of patients reversed using sugammadex was similar to that recorded in patients reversed using neostigmine-atropine. When heart rate was compared, there was a significant difference between basal values and those obtained at 30 seconds and 10 minutes after extubation in the neostigmine-atropine group. Extubation time (time from withdrawal of anesthetic gas to extubation) was significantly shorter in the sugammadex group (p = 0.003) than in the neostigmine -atropine group. The postextubation IOP values of the sugammadex group were similar to the neostigmine-atropine group. Extubation time (time from withdrawal of anesthetic gas to extubation) was significantly shorter in the sugammadex group (p = 0.003) than in the neostigmine-atropine group. Copyright (C) 2016, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. |
| Databáze: | OpenAIRE |
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