One-for-all phototheranostics: Single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy
| Autor: | Haifei Wen, Dong Wang, Yonghong Tan, Heng Guo, Wenhan Xu, Lei Xi, Ziyao Wen, Haoxuan Li, Kai Li, Jiachang Huang, Ben Zhong Tang, Qian Wu, Miaomiao Kang, Youmei Li, Lei Wang, Zhijun Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Biocompatibility Biophysics Cancer therapy Photoacoustic imaging in biomedicine Bioengineering Nanotechnology 02 engineering and technology Theranostic Nanomedicine Photothermal conversion Multi modality Photoacoustic Techniques Biomaterials Mice 03 medical and health sciences Neoplasms Animals Precision Medicine 030304 developmental biology 0303 health sciences Single component Photothermal therapy 021001 nanoscience & nanotechnology Fluorescence Photochemotherapy Mechanics of Materials Ceramics and Composites Nanoparticles 0210 nano-technology |
| Zdroj: | Biomaterials. 274:120892 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2021.120892 |
| Popis: | Construction of single component theranostic agent with one-for-all features to concurrently afford both multi-modality imaging and therapy is an appealing yet significantly challenging task. Herein, a type of luminogens with aggregation-induced emission (AIE) characteristics are tactfully designed and facilely synthesized. These AIE luminogens (AIEgens) exhibit long emission wavelengths, good photostability, remarkable biocompatibility, good reactive oxygen species (ROS) generation performance and excellent photothermal conversion efficiency, which allow them to be powerfully utilized for in vitro and in vivo cancer phototheranostics. The results show that one of the AIEgens is capable of precisely diagnosing solid tumors of mice by means of combined near-infrared-I/II (NIR-I/II) fluorescence-photoacoustic imaging, meanwhile this AIEgen can activate photodynamic and photothermal synergistic therapy (PDT-PTT) upon laser irradiation, resulting in excellent tumor elimination efficacy with only once injection and irradiation. This study thus provides a versatile platform for practical cancer theranostics. |
| Databáze: | OpenAIRE |
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