Mucus, Microbiomes and Pulmonary Disease
| Autor: | Sanjay H. Chotirmall, Oliver W. Meldrum |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Lung microbiome QH301-705.5 Population Medicine (miscellaneous) microbiome Review General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine mucin mucus medicine Microbiome Biology (General) education pulmonary disease education.field_of_study Lung business.industry Respiratory disease Mucin respiratory system medicine.disease Mucus 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Immunology business Respiratory tract |
| Zdroj: | Biomedicines, Vol 9, Iss 675, p 675 (2021) Biomedicines |
| ISSN: | 2227-9059 |
| Popis: | The respiratory tract harbors a stable and diverse microbial population within an extracellular mucus layer. Mucus provides a formidable defense against infection and maintaining healthy mucus is essential to normal pulmonary physiology, promoting immune tolerance and facilitating a healthy, commensal lung microbiome that can be altered in association with chronic respiratory disease. How one maintains a specialized (healthy) microbiome that resists significant fluctuation remains unknown, although smoking, diet, antimicrobial therapy, and infection have all been observed to influence microbial lung homeostasis. In this review, we outline the specific role of polymerizing mucin, a key functional component of the mucus layer that changes during pulmonary disease. We discuss strategies by which mucin feed and spatial orientation directly influence microbial behavior and highlight how a compromised mucus layer gives rise to inflammation and microbial dysbiosis. This emerging field of respiratory research provides fresh opportunities to examine mucus, and its function as predictors of infection risk or disease progression and severity across a range of chronic pulmonary disease states and consider new perspectives in the development of mucolytic treatments. |
| Databáze: | OpenAIRE |
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