CoQ10 exerts hepatoprotective effect in fructose-induced fatty liver model in rats
| Autor: | Amira E Alsemeh, Shimaa M. Elshazly, Enssaf Ahmad Ahmad, Samar Rezq |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Ubiquinone Oxidative phosphorylation Fructose Protective Agents 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Rats Wistar Receptor Pharmacology Liver injury Adiponectin receptor 1 Adiponectin medicine.diagnostic_test Fatty liver General Medicine medicine.disease Rats Fatty Liver Oxidative Stress Endocrinology chemistry Liver 030220 oncology & carcinogenesis Lipid profile 030217 neurology & neurosurgery |
| Zdroj: | Pharmacological reports : PR. 72(4) |
| ISSN: | 2299-5684 |
| Popis: | Excess dietary sugar is associated with deleterious metabolic effects, liver injury, and coenzyme-Q10 (CoQ10) deficiency. This study investigates the ability of CoQ10 to protect against fructose-induced hepatic damage. Rats were fed tap water or 30% fructose for 12 weeks with or without CoQ10 (10 mg/kg, po). An additional group of rats were allowed to feed on either water or 30% fructose for 12 weeks, followed by four weeks of treatment with either the vehicle or CoQ10. Fructose-fed rats showed lower CoQ10 levels, increased systolic pressure, increased body weight, higher liquid consumption, decreased food intake and hyperglycemia. Fructose-fed rats also showed deteriorated serum and liver lipid profiles, impaired liver function tests and oxidative status, and lower expression of adiponectin receptor 1 and 2 along with higher GLUT-2 levels. Furthermore, following fructose treatment, tyrosine kinase-PI3K pathway was inhibited. Additionally, there was an increase in the levels of apoptotic markers and serum visfatin and a decrease in the levels of adiponectin and soluble receptor of the advanced glycated end product. Consequently, several histopathological changes were detected in the liver. Concurrent or three months post-exposure administration of CoQ10 in fructose rats significantly reversed or attenuated all the measured parameters and hepato-cytoarchitecture alterations. This study suggests CoQ10 supplement as a possible prophylaxis or treatment candidate for fructose-induced liver injury. |
| Databáze: | OpenAIRE |
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