Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI
| Autor: | Donald W. Marion, Joanne K. Schiding, Patrick M. Kochanek, Donald S. Williams, Kristy S. Hendrich, Kimberly D. Statler, Chien Ho, John A. Melick |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Pentobarbital medicine.drug_class Anesthesia General Fentanyl Rats Sprague-Dawley medicine Animals Radiology Nuclear Medicine and imaging Cerebral perfusion pressure Anesthetics Isoflurane business.industry Brain Magnetic Resonance Imaging Rats Cerebral blood flow Barbiturate Cerebrovascular Circulation Anesthesia Anesthetic business Perfusion medicine.drug |
| Zdroj: | Magnetic Resonance in Medicine. 46:202-206 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.1178 |
| Popis: | The influence of anesthetic agents on cerebral blood flow (CBF) was tested in normal rats. CBF is quantified with arterial spin-labeled MRI in rats anesthetized with either an opiate (fentanyl), a potent inhalation anesthetic agent (isoflurane), or a barbiturate (pentobarbital) using doses commonly employed in experimental paradigms. CBF values were found to be about 2.5-3 times lower in most regions analyzed during anesthesia with either fentanyl (with N(2)O/O(2)) or pentobarbital vs. isoflurane (with N(2)O/O(2)), in agreement with findings utilizing invasive measurement techniques. CBF was heterogeneous in rats anesthetized with isoflurane (with N(2)O/O(2)), but relatively homogeneous in rats anesthetized with either fentanyl (with N(2)O/O(2)) or pentobarbital, also in agreement with studies using other techniques. Magn Reson Med 46:202-206, 2001. |
| Databáze: | OpenAIRE |
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