Malignant Potential of Gastrointestinal Cancers Assessed by Structural Equation Modeling
| Autor: | Haruo Shimizu, Kentaro Yamashita, Hiroaki Takahashi, Yasuhisa Shinomura, Kentaro Kawakami, Hirokazu Oohashi, Junichi Kodaira, Hiroyuki Isshiki, Kei Onodera, Satoshi Okahara, Masao Hosokawa, Yoshiaki Arimura |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Male Colorectal cancer Lymphovascular invasion lcsh:Medicine Metastasis 0302 clinical medicine Basic Cancer Research Gastrointestinal Cancers Medicine and Health Sciences Genitourinary Cancers lcsh:Science Gastrointestinal Neoplasms Aged 80 and over Multidisciplinary Esophageal cancer Middle Aged Immunohistochemistry 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Anatomy Research Article Adult medicine.medical_specialty Histology Esophageal Cancer Urology Gastroenterology and Hepatology Structural equation modeling Lymphatic System 03 medical and health sciences Internal medicine Gastrointestinal Tumors medicine Humans Matrilysin Aged Neoplasm Staging Colorectal Cancer business.industry lcsh:R Cancer Cancers and Neoplasms Biology and Life Sciences Models Theoretical medicine.disease Genitourinary Tract Tumors Cross-Sectional Studies lcsh:Q Lymph Nodes Neoplasm Grading business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 2, p e0149327 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Background Parameters reported in pathologic reviews have been failing to assess exactly the malignant potential of gastrointestinal cancers. We hypothesized that malignant potential could be defined by common latent variables (hypothesis I), but there are substantial differences in the associations between malignant potential and pathologic parameters according to the origin of gastrointestinal cancers (hypothesis II). We shed light on these issues by structural equation modeling. Materials and Methods We conducted a cross-sectional survey of 217 esophageal, 192 gastric, and 175 colorectal cancer patients who consecutively underwent curative surgery for their pathologic stage I cancers at Keiyukai Sapporo Hospital. Latent variables identified by factor analysis and seven conventional pathologic parameters were introduced in the structural equation modeling analysis. Results Because latent variables were disparate except for their number, 'three' in the examined gastrointestinal cancers, the first hypothesis was rejected. Because configural invariance across gastrointestinal cancers was not approved, the second hypothesis was verified. We could trace the three significant paths on the causal graph from latent variables to lymph node metastasis, which were mediated through depth, lymphatic invasion, and matrilysin expression in esophageal cancer, whereas only one significant path could be traced in both gastric and colorectal cancer. Two of the three latent variables were exogenous in esophageal cancer, whereas one factor was exogenous in the other gastrointestinal cancers. Cancer stemness promoted viability in esophageal cancer, but it was suppressed in others. Conclusion These results reflect the malignant potential of esophageal cancer is higher than that of the other gastrointestinal cancers. Such information might contribute to refining clinical treatments for gastrointestinal cancers. |
| Databáze: | OpenAIRE |
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