Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3)
| Autor: | Meir J. Stampfer, Ulrika Ericson, Christopher A. Haiman, Edward Giovannucci, Kala Visvanathan, Victoria L. Stevens, Alan A. Arslan, Cynthia A Thomsen, Judith A. Hoffman Bolton, Ross L. Prentice, Marjorie L. McCullough, Per Magne Ueland, Anne Zeleniuch-Jacquotte, Qiuyin Cai, Neal D. Freedman, Gianluca Severi, David C. Muller, Arnulf Langhammer, Howard D. Sesso, Stephanie A. Smith-Warner, Lynne R. Wilkens, Neil E. Caporaso, Julie E. Buring, William J. Blot, Jonas Manjer, Øivind Midttun, Kjell Grankvist, Demetrius Albanes, Mary Pettinger, Graham G. Giles, Yu Tang Gao, Mark P. Purdue, Yong-Bing Xiang, I-Min Lee, Xuehong Zhang, Lesley M. Butler, Woon-Puay Koh, Caroline L Relton, Honglan Li, Jiali Han, Mattias Johansson, Mikael Johansson, Loic Le Marchand, Regina G. Ziegler, Jie Wu, Paul Brennan, Qing Lan, Wei Zheng, Renwei Wang, Arve Ulvik, J. Michael Gaziano, Marit Næss, Anouar Fanidi, Xiao-Ou Shu, Jian-Min Yuan, Steinar Krokstad, Stephanie J. Weinstein, Allison M. Hodge |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research Pathology Lung Neoplasms chemistry.chemical_compound Methionine 0302 clinical medicine Risk Factors Prospective Studies Cotinine Prospective cohort study Aged 80 and over Incidence Incidence (epidemiology) Smoking Articles Middle Aged Europe 030220 oncology & carcinogenesis Cohort Female Adult medicine.medical_specialty Asia 03 medical and health sciences Folic Acid Sex Factors Internal medicine medicine Humans Oncology & Carcinogenesis Lung cancer Aged business.industry Australia Case-control study Protective Factors medicine.disease United States Vitamin B 6 B vitamins 030104 developmental biology chemistry Case-Control Studies business 1112 Oncology And Carcinogenesis |
| Zdroj: | JNCI: Journal of the National Cancer Institute. 110:57-67 |
| ISSN: | 1460-2105 0027-8874 |
| Popis: | Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown. Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status. Centralized biochemical analyses were performed to measure circulating concentrations of vitamin B6, folate, and methionine, as well as cotinine as an indicator of recent tobacco exposure. The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models. Results: Participants with higher circulating concentrations of vitamin B6 and folate had a modestly decreased risk of lung cancer risk overall, the odds ratios when comparing the top and bottom fourths (OR 4vs1 ) being 0.88 (95% confidence interval [CI] = 0.78 to 1.00) and 0.86 (95% CI = 0.74 to 0.99), respectively. We found stronger associations among men (vitamin B6: OR 4vs1 = 0.74, 95% CI = 0.62 to 0.89; folate: OR 4vs1 = 0.75, 95% CI = 0.61 to 0.93) and ever smokers (vitamin B6: OR 4vs1 = 0.78, 95% CI = 0.67 to 0.91; folate: OR 4vs1 = 0.87, 95% CI = 0.73 to 1.03). We further noted that the association of folate was restricted to Europe/Australia and Asia, whereas no clear association was observed for the United States. Circulating concentrations of methionine were not associated with lung cancer risk overall or in important subgroups. Conclusions: Although confounding by tobacco exposure or reverse causation cannot be ruled out, these study results are compatible with a small decrease in lung cancer risk in ever smokers who avoid low concentrations of circulating folate and vitamin B6. |
| Databáze: | OpenAIRE |
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