Effect of sodium nitrite on the execution of defensive and inhibitory conditioned reflexes
| Autor: | G. I. Shul'gina |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Conditioning Classical Stimulus (physiology) Nitric Oxide Inhibitory postsynaptic potential chemistry.chemical_compound Receptors GABA Escape Reaction Internal medicine Reflex medicine Animals Sodium nitrite Receptor Dose-Response Relationship Drug Sodium Nitrite Chemistry General Neuroscience Hyperpolarization (biology) Inhibition Psychological Endocrinology Disinhibition Anesthesia GABAergic Rabbits medicine.symptom Photic Stimulation |
| Zdroj: | Neuroscience and Behavioral Physiology. 28:278-284 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/bf02462957 |
| Popis: | Administration of sodium nitrite (an NO-generating preparation) doses of 11 mg/kg to rabbits was followed by motor disinhibition, with increases in myogram amplitudes in responses to nonreinforced flashes presented on a background of continuous illumination which served as a conditioned inhibitory stimulus; these changes appeared 1-1.5 h after administration and lasted throughout the 4-h observation period. After sodium nitrite doses of 5.5 mg/kg, responses to conditioned inhibition showed only a tendency to motor disinhibition. These results can be explained in terms of the ability of sodium nitrite to inhibit the function of GABAergic receptors, as development of internal inhibition is accompanied by increased inhibitory hyperpolarization processes in which the GABAergic mediator system is involved. The lower and higher sodium nitrite doses produced no increases in myogram amplitudes in responses to combinations of flashes of light and pain reinforcement, as occurred when these stimuli were presented to controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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