Treatment with poly I.C. enhances lipid peroxidation and the activity of xanthine oxidase, and decreases hepatic P-450 content and activities in mice and rats
| Autor: | Roy L. Walford, Toshiko Imamura, Akio Koizumi |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Lipid Peroxides Xanthine Oxidase Biophysics Biochemistry Carboxylesterase Mixed Function Oxygenases Lipid peroxidation Mice chemistry.chemical_compound Cytochrome P-450 Enzyme System Animals Xanthine oxidase Xenobiotic metabolizing enzymes Molecular Biology Glutathione Transferase Epoxide Hydrolases Interferon inducer Hepatic cytochrome NADH Dehydrogenase Cell Biology Rats Enzyme Activation Poly I-C chemistry Microsomes Liver Carboxylic Ester Hydrolases |
| Zdroj: | Biochemical and Biophysical Research Communications. 134:632-637 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(86)80466-1 |
| Popis: | Treatment of mice and rats with polyriboinosinic acid-polyribocytidylic acid (poly I.C., 5 mg/kg i.p.), a potent interferon inducer, decreased hepatic cytochrome P-450 system content and activities without influencing P-450-independent xenobiotic metabolizing enzymes. Treatment with poly I.C. decreased the content of P-450 by 28% in mice (P less than 0.05) and 30% in rats (P less than 0.05) but did not alter the activity of cytochrome c reductase. With treatment of poly I.C., the activity of XO increased 87% in mice (P less than 0.01) and 30% in rats (P less than 0.01). Lipid peroxidation was enhanced by 82% in mice (P less than 0.01) and 95% in rats (P less than 0.05). These results raise the possibility that a part of the depression of P-450 system content and activities by poly I.C. might be caused by enhanced lipid peroxidation associated with increased activity of XO. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|