Neurogenesis in the olfactory bulb of the frog Xenopus laevis shows unique patterns during embryonic development and metamorphosis
| Autor: | Dennis L. Gorlick, Anne Fritz, Gail D. Burd |
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| Rok vydání: | 1996 |
| Předmět: |
African clawed frog
Thyroid Hormones media_common.quotation_subject Sensory system Biology Xenopus laevis Developmental Neuroscience Interneurons medicine Animals Neurons Afferent Metamorphosis Axon media_common Neurons Embryogenesis Neurogenesis Metamorphosis Biological Anatomy Gastrula biology.organism_classification Olfactory Bulb Olfactory bulb medicine.anatomical_structure nervous system Larva Neural development Developmental Biology |
| Zdroj: | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 14(7-8) |
| ISSN: | 0736-5748 |
| Popis: | We determined the time of origin of neurons in the olfactory bulb of the South African clawed frog, Xenopus laevis . Tritiated thymidine injections were administered to frog embryos and tadpoles from gastrulation (stage 11/12) through metamorphosis (stage 65), paraffin sections were processed for autoradiography, and the distribution of heavily and lightly labeled cells was examined. In the ventral olfactory bulb, we observed that the mitral cells were born as early as stage 11/12 and continued to be generated through the end of metamorphosis. Interneurons (periglomerular and granule cells) were not born in the ventral bulb until stage 41, and birth of these cells also continued through metamorphosis. Labeled cells were observed in the accessory olfactory bulb, beginning at stage 41. In contrast, the cells of the dorsal olfactory bulb were not born until the onset of metamorphosis (stage 54); at this stage in the dorsal bulb, the genesis of mitral cells, interneurons, and glial cells completely overlapped. The results indicate that olfactory axon innervation is not necessary to induce early stages of neurogenesis in the ventral olfactory bulb. On the other hand, the results on the dorsal olfactory bulb are consistent with the hypothesis that innervation from new or transformed sensory neurons in the principal cavity induces neurogenesis in the dorsal bulb. |
| Databáze: | OpenAIRE |
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