Soluble TREM2 and inflammatory proteins in Alzheimer's disease cerebrospinal fluid
| Autor: | Alzheimer’s Disease Neuroimaging Initiative, Boris-Stephan Rauchmann, Angélique Sadlon, Robert Perneczky |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
Male 0301 basic medicine psychology [Alzheimer Disease] medicine.medical_treatment cerebrospinal fluid [Amyloid beta-Peptides] Cohort Studies pharmacology [Cytokines] 0302 clinical medicine Cerebrospinal fluid Medicine Receptors Immunologic Aged 80 and over Membrane Glycoproteins biology General Neuroscience Neurodegeneration Neurodegenerative Diseases General Medicine Middle Aged Mental Status and Dementia Tests cerebrospinal fluid [Alzheimer Disease] cerebrospinal fluid [Cognitive Dysfunction] cerebrospinal fluid [Inflammation] pharmacology [Lipopolysaccharides] pharmacology [Steroids] Psychiatry and Mental health Clinical Psychology Cytokine cerebrospinal fluid [Biomarkers] cerebrospinal fluid [Cytokines] Cytokines Biomarker (medicine) Steroids Female psychology [Cognitive Dysfunction] cerebrospinal fluid [Membrane Glycoproteins] Antibody Immunoglobulins tau Proteins 03 medical and health sciences Alzheimer Disease Humans Dementia Cognitive Dysfunction ddc:610 Neuroinflammation Aged Inflammation Amyloid beta-Peptides Action intention and motor control business.industry TREM2 medicine.disease cerebrospinal fluid [Immunoglobulins] 030104 developmental biology cerebrospinal fluid [tau Proteins] Immunology biology.protein cerebrospinal fluid [Neurodegenerative Diseases] Geriatrics and Gerontology business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease, 73, 1615-1626 Journal of Alzheimer's disease 73(4), 1615-1626 (2020). doi:10.3233/JAD-191120 Journal of Alzheimer's Disease, 73, 4, pp. 1615-1626 |
| ISSN: | 1387-2877 |
| DOI: | 10.3233/JAD-191120 |
| Popis: | Contains fulltext : 220327.pdf (Publisher’s version ) (Closed access) The present study explores the associations of soluble TREM2, an important regulator of microglial activity linked to Alzheimer's disease (AD), with other known inflammatory proteins in cerebrospinal fluid (CSF). We studied 303 participants, including 89 controls, 135 mild cognitive impairment, and 79 AD dementia patients. Using established CSF biomarkers, subjects were classified according to the National Institute on Aging-Alzheimer's Association research framework, which groups markers into those of amyloid-beta deposition (A), tau pathology (T), and neurodegeneration (N). TNFR1, TNFR2, TGF-beta 1, TGF beta 2, IL-9, TNF-alpha, ICAM1, and VCAM1 showed significant concentration differences between the ATN groups, with higher concentrations in more advanced disease categories. sTREM2 was positively associated with the pro-inflammatory proteins TNF-a, TNFR1, TNFR2, ICAM1, VCAM1, and IP-10 and negatively with IL-21; also, positive associations with the anti-inflammatory proteins TGF beta 1, IL-10, and IL-9 were found. Pathway enrichment analysis highlighted the involvement of sTREM2 in key functional clusters including immunoglobulin and cytokine production and cellular response to lipopolysaccharides, cytokines, and steroid hormones. Our work provides further evidence in support of TREM2 as amarker of neuroinflammatory response in AD. 12 p. |
| Databáze: | OpenAIRE |
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