Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes

Autor: Jerome Etienne, S.B. Zriouil, C.E. Ramarokoto, Jean-David Perrier-Gros-Claude, Cheikh Fall, P. Boisier, Sébastien Breurec, F. Diene-Sarr, Régis Pouillot, Benoit Garin, Jean-Michel Thiberge, S. Djibo, Frédéric Laurent, Frédérique Randrianirina, Sylvain Brisse, M.C. Fonkoua
Přispěvatelé: Institut Pasteur de Dakar, Réseau International des Instituts Pasteur (RIIP), Centre Pasteur du Cameroun, Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), Institut Pasteur [Paris], Centre National de Reference des Staphylocoques, Université de Lyon, Institut Pasteur du Maroc, Institut Pasteur de Madagascar, Ibn Rochd University Hospital, Faculté des Sciences et Techniques [Settat] (FSTS), Université Hassan 1er [Settat], Institut Pasteur [Paris] (IP)
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
methicillin-susceptible Staphylococcus aureus
medicine.disease_cause
community-acquired infections
Methicillin
Leukocidins
Genotype
Prevalence
Cluster Analysis
Child
Aged
80 and over
0303 health sciences
Molecular Epidemiology
General Medicine
respiratory system
Middle Aged
Staphylococcal Infections
3. Good health
Anti-Bacterial Agents
Bacterial Typing Techniques
Panton-Valentine leukocidin
Infectious Diseases
Staphylococcus aureus
Child
Preschool
Population study
Female
Adult
Microbiology (medical)
hospital infections
Adolescent
Virulence Factors
Bacterial Toxins
Exotoxins
Microbial Sensitivity Tests
Biology
Staphylococcal infections
Microbiology
03 medical and health sciences
Young Adult
clones
parasitic diseases
medicine
Humans
Panton–Valentine leukocidin
030304 developmental biology
Aged
Molecular epidemiology
030306 microbiology
Infant
biochemical phenomena
metabolism
and nutrition
medicine.disease
bacterial infections and mycoses
Virology
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Africa
Multilocus sequence typing
bacteria
Methicillin Susceptible Staphylococcus Aureus
Multilocus Sequence Typing
Zdroj: Clinical Microbiology and Infection
Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2011, 17 (4), pp.633-639. ⟨10.1111/j.1469-0691.2010.03320.x⟩
Clinical Microbiology and Infection, 2011, 17 (4), pp.633-639. ⟨10.1111/j.1469-0691.2010.03320.x⟩
ISSN: 1198-743X
1469-0691
Popis: International audience; The epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) in Africa is poorly documented. From January 2007 to March 2008, 555 S. aureus isolates were collected from five African towns in Cameroon, Madagascar, Morocco, Niger, and Senegal; among these, 456 unique isolates were susceptible to methicillin. Approximately 50% of the MSSA isolates from each different participating centre were randomly selected for further molecular analysis. Of the 228 isolates investigated, 132 (58%) belonged to five major multilocus sequence typing (MLST) clonal complexes (CCs) (CC1, CC15, CC30, CC121 and CC152) that were not related to any successful methicillin-resistant S. aureus (MRSA) clones previously identified in the same study population. The luk-PV genes encoding Panton-Valentine leukocidin (PVL), present in 130 isolates overall (57%), were highly prevalent in isolates from Cameroon, Niger, and Senegal (West and Central Africa). This finding is of major concern, with regard to both a source of severe infections and a potential reservoir for PVL genes. This overrepresentation of PVL in MSSA could lead to the emergence and spread of successful, highly virulent PVL-positive MRSA clones, a phenomenon that has already started in Africa.
Databáze: OpenAIRE
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