Association Between Bat Vitamin D Receptor 3' Haplotypes and Vitamin D Levels at Baseline and a Lower Response After Increased Vitamin D Supplementation and Exposure to Sunlight
| Autor: | D.A. de Luis, J. L. Pérez-Castrillón, Eladio Velasco, María Pérez-Alonso, Marta Ruiz-Mambrilla, José M. Olmos, Antonio Dueñas-Laita, Laisa-Socorro Briongos |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
TaqI Genotype Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism Calcitriol receptor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Chiroptera Vitamin D and neurology medicine Animals Humans 030212 general & internal medicine Prospective Studies Vitamin D Cholecalciferol Sunlight Nutrition and Dietetics business.industry Haplotype General Medicine Endocrinology chemistry Haplotypes Dietary Supplements Increased vitamin D Receptors Calcitriol Female business |
| Zdroj: | International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 90(3-4) |
| ISSN: | 0300-9831 |
| Popis: | Abstract. Objective: The aim of this study was to evaluate the relationship between vitamin D levels at baseline and after 12 weeks of supplementation/exposure to sunlight and VDR genotypes (BsmI, TaqI and ApaI) and haplotypes in a homogeneous population of postmenopausal women. Methods: We made a prospective study in which 151 women were randomized to two groups: One with 1000 mg of calcium and 800 IU vitamin D supplementation (102 women) and a placebo group with neither calcium or vitamin D supplementation (49 women). The follow-up was from May to September 2012.Vitamin D was determined by chemiluminescent immunoassay. Genotypes were determined using the Sequenomi Plexplatform and haplotypes using PHASE software. Results: Baseline (25 ± 10 ng/ml vs.23 ± 9 ng/ml, p > 0.05) and 12-week (32 ± 8 ng/ml vs.29 ± 10 ng/ml, p > 0.05) vitamin D levels were similar between the two groups. The genetic study was made in the total population. There were no differences in baseline and final levels of vitamin D in terms of genotypes and haplotypes, except for the Bat haplotype, whose baseline values were lower (25OHD: 21 ± 10 ng/ml vs. 21 ± 10 ng/ml, p = 0.038). The rate of nonresponders in this group was 15 % (p = 0.001), compared with 9 %, 2 % and 3 % in the other groups. Conclusions: The Bat haplotype was associated with lower baseline levels of vitamin D and a worse response to supplementation and, therefore, may be a risk factor for vitamin D deficiency. |
| Databáze: | OpenAIRE |
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