Topical antimicrobial photodynamic therapy improves angiogenesis in wounds of diabetic mice
| Autor: | Mrinalini Sharma, Pradeep Kumar Gupta, Khageswar Sahu, Alok Dube |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Angiogenesis Administration Topical medicine.medical_treatment Drug Evaluation Preclinical Photodynamic therapy Dermatology Pharmacology Nitric Oxide p38 Mitogen-Activated Protein Kinases Diabetes Mellitus Experimental Proinflammatory cytokine Nitric oxide Neovascularization Mice chemistry.chemical_compound Diabetes mellitus medicine Animals Phosphorylation Wound Healing Neovascularization Pathologic business.industry NF-kappa B medicine.disease Anti-Bacterial Agents Vascular endothelial growth factor Photochemotherapy chemistry Immunology Wound Infection Silver Nitrate Female Surgery Lasers Semiconductor medicine.symptom Wound healing business |
| Zdroj: | Lasers in Medical Science. 30:1923-1929 |
| ISSN: | 1435-604X 0268-8921 |
| DOI: | 10.1007/s10103-015-1784-8 |
| Popis: | We report the results of our investigations on the effect of antimicrobial photodynamic therapy (APDT) on angiogenesis in wounds of diabetic mice. For this, measurements were made on levels of nitric oxide (NO), vascular endothelial growth factor-A (VEGF-A), and markers of proinflammatory stress (phosphorylated nuclear factor kappa B and p(38) mitogen-activated protein kinase) on day 3 post-wounding. For uninfected and infected wounds, the levels of NO, VEGF-A were lower and the levels of phospho-NF-kB-p65, phospho-p(38)MAPK were higher in diabetic mice compared with that in nondiabetic mice. For infected wounds, multiple APDT (fluence ~60 J/cm(2)) led to increase in NO, VEGF-A levels and a decrease in the phospho-NF-kB-p65, phospho-p(38)MAPK. Further, compared with aminoguanidine, and silver nitrate, multiple APDT was observed to result in a much improved proangiogenic response. |
| Databáze: | OpenAIRE |
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