Factors Affecting Side Effects, Seroconversion Rates and Antibody Response After Inactivated SARS-CoV-2 Vaccination in Healthcare Workers
| Autor: | Beyhan Cengiz Özyurt, Gülizar Deniz, Sinem Akcali, Erhan Eser, Fatma Merve Gezginci, Yunus Özkaya, Deniz Özer, Pinar Dundar Erbay, Ferya Karadağ Yalçın, Şebnem Şenol Akar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty COVID-19 Vaccines Adolescent Side effect Health Personnel Antibodies Viral Young Adult Internal medicine Humans Medicine Seroconversion Neutralizing antibody Univariate analysis General Immunology and Microbiology biology SARS-CoV-2 business.industry Vaccination COVID-19 Middle Aged Exact test Infectious Diseases Antibody Formation biology.protein RNA Viral Female Analysis of variance Antibody business |
| Zdroj: | Mikrobiyoloji Bulteni. 55:519-538 |
| ISSN: | 0374-9096 |
| DOI: | 10.5578/mb.20219705 |
| Popis: | In this study, it was aimed to prospectively evaluate the efficacy, side effects and seroconversion data of inactive severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), CoronaVac® (Sinovac, China) vaccine in healthcare workers. A total of 1053 healthcare workers who were initially seronegative (COV2T® SARS-CoV-2 Total Siemens, USA) and vaccinated with inactivated SARS-CoV-2 were included in the study. Quantitative IgG antibodies (ADVIA Centaur® SARS-CoV-2 IgG, Siemens, USA) were investigated 28 days after the first vaccine (n= 939) and the second vaccine (n= 771). In addition, neutralizing antibodies were evaluated via "enzyme linked immunosorbent assay (ELISA)" test (ACE2-RBD Neutralization Assay, Dia-Pro, Italy) 28 days after the first vaccine. Antibody response of the vaccine was evaluated statistically by univariate (Chi-square, Fisher's exact test, Student's t test, Mann-Whitney U, one-way ANOVA and Kruskall Wallis ANOVA tests) analysis and linear regression models. The consistency between quantitative IgG test and neutralizing antibody test was also evaluated in blood samples taken 28 days after second vaccination. Statistical analysis was determined in logarithmically transformed data with statistical analysis with SPSS 23.0 and Stata, and type 1 error level was accepted as 0.05. At least one side effect was reported by 31.3% and 26.8% of the participants after the first and second vaccine, respectively. The most frequent side effect was pain at the injection site with a frequency of 20.4% vs 21.7%. The frequency of applying to a health center due to side effects was 1.0% after the first vaccine and 0.8% after the second vaccine. The percentage of those who produced sufficient quantitative IgG was found as 25.3% (95% CI= 22.5-28.1) 28 days after the first vaccine and 97.9% (95% CI= 96.91- 98.93) after the second vaccine. Neutralizing test antibody positivity was found as 97.7% 28 days after the second vaccine. In univariate analysis, the characteristics that significantly increased the quantitative IgG response against inactivated SARS-CoV-2 vaccine were young age (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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