Adrenocortical stimulation by a cholecystokinin preparation in the rat
| Autor: | Kunihiro Odaguchi, Goro Katsuura, Shinji Itoh, Ryoji Hirota |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Pituitary gland Time Factors medicine.medical_treatment Intraperitoneal injection Peptide Stimulation In Vitro Techniques Vagotomy digestive system General Biochemistry Genetics and Molecular Biology Motilin chemistry.chemical_compound Corticosterone Internal medicine Medicine Animals Secretion General Pharmacology Toxicology and Pharmaceutics Cholecystokinin Hypophysectomy Injections Intraventricular chemistry.chemical_classification business.industry digestive oral and skin physiology General Medicine Stimulation Chemical Rats Endocrinology medicine.anatomical_structure chemistry Pituitary Gland Adrenal Cortex business hormones hormone substitutes and hormone antagonists Injections Intraperitoneal |
| Zdroj: | Life sciences. 25(20) |
| ISSN: | 0024-3205 |
| Popis: | The effect of a cholecystokinin (CCK) preparation on the secretion of corticosterone when injected intraperitoneally and intraventricularly was studied in the rat. Both routes of injections produced pronounced elevation of plasma corticosterone levels, but the minimum effective dose by intraventricular injection was 10 mU/rat and that by intraperitoneal injection 2 U/100 g, or approximately 5 U/rat. Although the effect was observed in vagotomized rats, CCK did not affect the pituitary gland itself. It was inferred that CCK acts directly or indirectly on CRF neurones in the brain. Since CCK preparation used in the present experiments was contaminated with motilin, the effect of synthetic motilin on the adrenocortical secretion was also examined. However, no stimulatory effect was found following intraventricular injection of this peptide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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