Association of Self-Rated Pain with Clinical Peri-Implant Parameters and Cytokine Profile in Smokers and Never Smokers with and without Peri-Implantitis
| Autor: | Firas K. Alqarawi, Abdulrahman M AlMubarak, Paras Ahmad, Samar Al-Saleh, Fahim Vohra, Faris A. Alshahrani, Eman M. AlHamdan, Montaser N Alqutub, Tariq Abduljabbar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Peri-implantitis Technology QH301-705.5 Cytokine profile peri-implant crevicular fluid QC1-999 Bleeding on probing Peri cigarette smoking Gastroenterology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine General Materials Science pain Biology (General) Instrumentation QD1-999 Fluid Flow and Transfer Processes business.industry Process Chemistry and Technology Physics General Engineering 030206 dentistry Engineering (General). Civil engineering (General) cytokines Computer Science Applications Never smokers Chemistry inflammation Biomarker (medicine) Implant medicine.symptom TA1-2040 business 030217 neurology & neurosurgery peri-implantitis |
| Zdroj: | Applied Sciences, Vol 11, Iss 5559, p 5559 (2021) Applied Sciences Volume 11 Issue 12 |
| ISSN: | 2076-3417 |
| Popis: | To examine the association between self-perceived pain (SPP), clinical and radiographic peri-implant parameters, and biomarker levels among smokers and never smokers with and without peri-implantitis. Sixty individuals (20 smokers with peri-implantitis [group-1], 20 never smokers with peri-implantitis [group-2] and 20 never smokers without peri-implantitis [control-group]) were included. SPP was evaluated using a numeric pain rating scale (NPRS). Peri-implant plaque index (PI), probing depth (PD), and bleeding on probing (BOP) were recorded. After obtaining the samples, the levels of TNF-α, MMP-1, and IL-8 were measured. The mean SPP score in group-1, group-2, and the control group was 1.3 ± 1, 3.4 ± 1, and zero, respectively. The peri-implant mean PD (p < 0.05), BOP (p < 0.05), PI (p < 0.05), and crestal bone loss (CBL) (p < 0.05) were significantly higher among test groups than the control group. The levels of TNF-α, MMP-1, and IL-8 were significantly raised among group-1 and group-2 than the control group. A significant correlation between increasing SPP and PICF TNF-α, MMP-1, and IL-8 levels was observed based on regression analysis. Proinflammatory biomarkers were higher in smokers with peri-implantitis than never smokers with and without peri-implantitis, with a significant association between the proinflammatory cytokines and SPP. |
| Databáze: | OpenAIRE |
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