Attenuation of human influenza a viruses
| Autor: | A. S. Beare, M. L. Bynoe |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Virus Cultivation
Human influenza Orthomyxoviridae Virulence Biology Antiviral Agents Virus Microbiology Antigen Humans Antigens General Environmental Science Clinical Trials as Topic Strain (chemistry) Attenuation General Engineering Papers and Originals General Medicine Hemagglutination Inhibition Tests biology.organism_classification Virology Cold Temperature Influenza Vaccines Antibody Formation General Earth and Planetary Sciences |
| Zdroj: | BMJ. 4:198-201 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.4.5677.198 |
| Popis: | The attenuation of two human influenza A viruses has been carried out, using the selection of inhibitor-resistant strains and multiple passages at low temperatures. A virus related to A2/Tokyo/3/67 was obtained in an inhibitor-resistant form. When this was compared with the inhibitor-sensitive strain in a volunteer trial it was relatively non-pathogenic. The second virus, A2/Hongkong/1/68, was subjected to much longer treatment, but nevertheless remained slightly sensitive to serum inhibitor. When given to volunteers it was less pathogenic than before but attenuation was incomplete. A2/Hongkong/1/68 was also modified by passage at low temperatures. Many of these passages are apparently necessary for full attenuation. All attenuated viruses were infective and antigenic. |
| Databáze: | OpenAIRE |
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