Flumazenil in the treatment of hepatic encephalopathy in children with fulminant liver failure
| Autor: | A. Rousset, C. Lanchier, C. Tahiri, Philippe Durand, Denis Devictor, Y. Navelet |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Flumazenil
medicine.medical_treatment Encephalopathy Liver transplantation Intensive Care Units Pediatric Critical Care and Intensive Care Medicine Bolus (medicine) medicine Humans Prospective Studies Child Hepatic encephalopathy Pediatric intensive care unit Coma business.industry Infant Electroencephalography medicine.disease Treatment Outcome Child Preschool Hepatic Encephalopathy Anesthesia medicine.symptom business Complication medicine.drug |
| Zdroj: | Intensive Care Medicine. 21:253-256 |
| ISSN: | 1432-1238 0342-4642 |
| Popis: | To evaluate the effect of flumazenil on hepatic encephalopathy complicating fulminant liver failure in children. Uncontrolled prospective study. Pediatric Intensive Care Unit, tertiary care center. 9 children with fulminant liver failure and hepatic encephalopathy awaiting emergency liver transplantation Changes in hepatic encephalopathy grade and in electroencephalogram were recorded during the injection of a bolus of flumazenil (0.01 mg/kg/IV bolus) followed by a continuous infusion of flumazenil (0.01mg/kg/h). Before flumazenil, 7 children had grade 2 and 2 had grade 3 hepatic encephalopathy. Flumazenil injection mediated an arousal effect in 1 child in whom encephalopathy improved from grade 3 to grade 2. This effect lasted 30 min. No clinical response was observed in other children. An improvement of EEG anomalies was observed lasting 3 min in one child. Despite continuous infusion of flumazenil, encephalopathy worsened in all children. The effect of intravenous administration of flumazenil on hepatic encephalopathy in children with fulminant liver failure is inconsistent. Its efficacy is transient. The therapeutic value of flumazenil in children with fulminant liver failure awaiting a liver graft is minimal at this dosage. |
| Databáze: | OpenAIRE |
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