Genetic factors contributing to hypertension in African‐based populations: A systematic review and meta‐analysis
| Autor: | Yandiswa Y Yako, Tandi E. Matsha, Anastase Dzudie, Eric V. Balti, Andre Pascal Kengne, Deirdre Kruger, Eugene Sobngwi, Charles Agyemang |
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| Přispěvatelé: | Internal Medicine, Faculty of Medicine and Pharmacy, Diabetes Pathology & Therapy, ACS - Atherosclerosis & ischemic syndromes, Public and occupational health, APH - Personalized Medicine, APH - Global Health, ACS - Diabetes & metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Single-nucleotide polymorphism Blood Pressure 030204 cardiovascular system & hematology Essential hypertension Hypertension/ethnology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Gene Frequency Polymorphism (computer science) Internal Medicine medicine Blood Pressure Variability Humans Genetic Predisposition to Disease 030212 general & internal medicine Allele Genetic Association Studies Genetic association business.industry African Continental Ancestry Group/genetics Odds ratio medicine.disease Confidence interval Meta-analysis Hypertension Cardiology and Cardiovascular Medicine business Demography |
| Zdroj: | J Clin Hypertens (Greenwich) Journal of clinical hypertension (Greenwich, Conn.), 20(3), 485-495. Wiley-Blackwell |
| ISSN: | 1524-6175 |
| Popis: | In a systematic review, the authors explored genetic association studies of essential hypertension in African populations. Studies reporting on the association of polymorphism(s) with hypertension in African populations were included. Appropriate studies were pooled using random effects model meta-analysis, under six potential inheritance models. In all, 46 polymorphisms in 33 genes were investigated for their association with hypertension or blood pressure levels. Meta-analysis was possible for three single nucleotide polymorphisms: rs4340, rs699, and rs5186. An association was found between rs5186, rs699, and hypertension under allele contrast and homozygous codominant models (odds ratio, 1.63 [95% confidence interval, 1.04–2.54] and 4.01 [95% confidence interval, 1.17–13.80] for rs5186, respectively; and 1.80 [95% confidence interval, 1.13–2.87] for rs699). Findings were mostly robust in sensitivity analyses. According to the systematic review, there is currently insufficient evidence on the specific polymorphisms that pose the risk of hypertension in African populations. Large-scale genetic studies are warranted to better understand susceptibility polymorphisms that may be specific to African populations. |
| Databáze: | OpenAIRE |
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