Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study
Autor: | Elisabeth Spitz, Dominique Fromage, Marion Trousselard, Eric Welter, Frederic Coatleven, Frédéric Dutheil, Jean-Luc Pouly, Lydie Cherier, Dominique Dallay, Anne-Laure Sutter-Dallay, Anaïs M Duffaud, Mélanie Balès, Dahlia Tharwat, Frédérique Teissèdre, Thierry Harvey |
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Přispěvatelé: | Groupe Hospitalier Diaconesses Croix Saint-Simon, Institut de Recherche Biomédicale des Armées (IRBA), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), CHU de Bordeaux Pellegrin [Bordeaux], Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), CHU Clermont-Ferrand, Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Australian Catholic University (ACU), Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA) |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Mindfulness
mindfulness Vulnerability [SHS]Humanities and Social Sciences [SCCO]Cognitive science stress 0302 clinical medicine Pregnancy Protocol Multicenter Studies as Topic Chronic stress Longitudinal Studies Prospective Studies ComputingMilieux_MISCELLANEOUS education.field_of_study General Medicine Allostatic load 3. Good health Mental Health Allostasis Female France allostatic load Clinical psychology Adult Adolescent postnatal depression Population education Context (language use) Depression Postpartum 03 medical and health sciences Young Adult medicine Humans business.industry Stressor medicine.disease 030227 psychiatry Pregnancy Complications Logistic Models Chronic Disease Multivariate Analysis [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business 030217 neurology & neurosurgery Biomarkers Stress Psychological |
Zdroj: | BMJ Open BMJ Open, BMJ Publishing Group, 2018, 8 (5), pp.e018317. ⟨10.1136/bmjopen-2017-018317⟩ BMJ Open, 2018, 8 (5), pp.e018317. ⟨10.1136/bmjopen-2017-018317⟩ |
ISSN: | 2044-6055 |
Popis: | Introduction The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one’s complete and non-judgemental attention to the present experience on a moment-to-moment basis). This psychological resource is linked to protective and resilient psychic functioning. Thus, PND appears to be a relevant model for studying the mechanisms of chronic stress and vulnerability to psychopathologies. In this article, we present the protocol of an ongoing study (started in May 2017). Methods and analysis The study is being carried out in five maternities and will involve 260 women. We aim to determine the predictive psychobiological factors for PND emergence and to provide a better insight into the mechanisms involved in chronic stress during pregnancy. We use a multidisciplinary approach that encompasses psychological resources and biophysiological and genetic profiles in order to detect relevant vulnerability biomarkers for chronic stress and the development of PND. To do so, each woman will be involved in the study from her first trimester of pregnancy until 12 months postdelivery. Ethics and dissemination Ethics approval was obtained from the Ile de France III Ethics Committee, France (2016-A00887-44). We aim to disseminate the findings through international conferences and international peer-reviewed journals. Trial registration number NCT03088319; Pre-results. |
Databáze: | OpenAIRE |
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