Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study

Autor: Elisabeth Spitz, Dominique Fromage, Marion Trousselard, Eric Welter, Frederic Coatleven, Frédéric Dutheil, Jean-Luc Pouly, Lydie Cherier, Dominique Dallay, Anne-Laure Sutter-Dallay, Anaïs M Duffaud, Mélanie Balès, Dahlia Tharwat, Frédérique Teissèdre, Thierry Harvey
Přispěvatelé: Groupe Hospitalier Diaconesses Croix Saint-Simon, Institut de Recherche Biomédicale des Armées (IRBA), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), CHU de Bordeaux Pellegrin [Bordeaux], Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), CHU Clermont-Ferrand, Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Australian Catholic University (ACU), Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Mindfulness
mindfulness
Vulnerability
[SHS]Humanities and Social Sciences
[SCCO]Cognitive science
stress
0302 clinical medicine
Pregnancy
Protocol
Multicenter Studies as Topic
Chronic stress
Longitudinal Studies
Prospective Studies
ComputingMilieux_MISCELLANEOUS
education.field_of_study
General Medicine
Allostatic load
3. Good health
Mental Health
Allostasis
Female
France
allostatic load
Clinical psychology
Adult
Adolescent
postnatal depression
Population
education
Context (language use)
Depression
Postpartum

03 medical and health sciences
Young Adult
medicine
Humans
business.industry
Stressor
medicine.disease
030227 psychiatry
Pregnancy Complications
Logistic Models
Chronic Disease
Multivariate Analysis
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
030217 neurology & neurosurgery
Biomarkers
Stress
Psychological
Zdroj: BMJ Open
BMJ Open, BMJ Publishing Group, 2018, 8 (5), pp.e018317. ⟨10.1136/bmjopen-2017-018317⟩
BMJ Open, 2018, 8 (5), pp.e018317. ⟨10.1136/bmjopen-2017-018317⟩
ISSN: 2044-6055
Popis: Introduction The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one’s complete and non-judgemental attention to the present experience on a moment-to-moment basis). This psychological resource is linked to protective and resilient psychic functioning. Thus, PND appears to be a relevant model for studying the mechanisms of chronic stress and vulnerability to psychopathologies. In this article, we present the protocol of an ongoing study (started in May 2017). Methods and analysis The study is being carried out in five maternities and will involve 260 women. We aim to determine the predictive psychobiological factors for PND emergence and to provide a better insight into the mechanisms involved in chronic stress during pregnancy. We use a multidisciplinary approach that encompasses psychological resources and biophysiological and genetic profiles in order to detect relevant vulnerability biomarkers for chronic stress and the development of PND. To do so, each woman will be involved in the study from her first trimester of pregnancy until 12 months postdelivery. Ethics and dissemination Ethics approval was obtained from the Ile de France III Ethics Committee, France (2016-A00887-44). We aim to disseminate the findings through international conferences and international peer-reviewed journals. Trial registration number NCT03088319; Pre-results.
Databáze: OpenAIRE