Immunohistochemical expression of vascular endothelial growth factor in canine oral squamous cell carcinomas
| Autor: | Lorenzo Lo Muzio, Brunella Restucci, Manuela Martano, Paola Maiolino, Dora Maria Ceccarelli |
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| Přispěvatelé: | Martano, Manuela, Restucci, Brunella, Ceccarelli, DORA MARIA, Lo Muzio, Lorenzo, Maiolino, Paola |
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty 040301 veterinary sciences Angiogenesis Biology Metastasis 0403 veterinary science 03 medical and health sciences Paracrine signalling chemistry.chemical_compound 0302 clinical medicine Dog medicine Autocrine signalling Cell growth Oral cancer Articles 04 agricultural and veterinary sciences medicine.disease Immunohistochemistry Vascular endothelial growth factor Endothelial stem cell stomatognathic diseases Oral squamous cell carcinoma Oncology chemistry 030220 oncology & carcinogenesis Canine Oral Squamous Cell Carcinoma |
| Zdroj: | Oncology Letters. 11:399-404 |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | Angiogenesis is crucial for the growth and metastasis of malignant tumours, and various proangiogenic factors promote this process. One of these factors is vascular endothelial growth factor (VEGF), which appears to play a key role in tumour angiogenesis. The aim of the present study was to assess whether VEGF expression is associated with angiogenesis, disease progression and neoplastic proliferation in canine oral squamous cell carcinoma (OSCC) tissue. VEGF immunoreactivity was quantified by immunohistochemistry in 30 specimens, including normal oral mucosa and OSCC tissues graded as well, moderately or poorly differentiated. VEGF expression was correlated with tumour cell proliferation, as assessed using the proliferating cell nuclear antigen (PCNA) marker and microvessel density (data already published). The present results revealed that VEGF and PCNA expression increased significantly between normal oral tissue and neoplastic tissue, and between well and moderately/poorly differentiated tumours. In addition, VEGF expression was strongly correlated with PCNA expression and microvessel density. It was concluded that VEGF may promote angiogenesis through a paracrine pathway, stimulating endothelial cell proliferation and, similarly, may induce tumour cell proliferation through an autocrine pathway. The present results suggest that the evaluation of VEGF may be a useful additional criterion for estimating malignancy and growth potential in canine OSCCs. |
| Databáze: | OpenAIRE |
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