Deconvoluting the Bioactivity of Calcium Phosphate-Based Bone Graft Substitutes: Strategies to Understand the Role of Individual Material Properties

Autor: Víctor Pablo Galván-Chacón, Pamela Habibovic
Přispěvatelé: Division Instructive Biomaterials Eng, RS: MERLN - Instructive Biomaterials Engineering (IBE)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
OSTEOGENIC DIFFERENTIATION
Materials science
Bone Regeneration
0206 medical engineering
Biomedical Engineering
Pharmaceutical Science
chemistry.chemical_element
Nanotechnology
MESENCHYMAL STROMAL CELLS
02 engineering and technology
Calcium
Regenerative Medicine
Regenerative medicine
Biomaterials
chemistry.chemical_compound
HYDROXYAPATITE COATINGS
Animals
Humans
Bone regeneration
Octacalcium phosphate
IN-VIVO
BETA-TRICALCIUM PHOSPHATE
GROWTH-FACTOR-BETA
Regeneration (biology)
Biomaterial
biomaterials design
021001 nanoscience & nanotechnology
property-function relationships
OSTEOBLAST-LIKE CELLS
020601 biomedical engineering
calcium phosphates
bone graft substitutes
biomaterials-biological systems interactions
chemistry
OCTACALCIUM PHOSPHATE
Bone Substitutes
Hydroxyapatite coating
SURFACE FREE-ENERGY
0210 nano-technology
Material properties
STEM-CELLS
Zdroj: Advanced Healthcare Materials, 6(13):1601478. Wiley
ISSN: 2192-2640
Popis: Calcium phosphate (CaP)-based ceramics are the most widely applied synthetic biomaterials for repair and regeneration of damaged and diseased bone. CaP bioactivity is regulated by a set of largely intertwined physicochemical and structural properties, such as the surface microstructure, surface energy, porosity, chemical composition, crystallinity and stiffness. Unravelling the role of each individual property in the interaction between the biomaterial and the biological system is a prerequisite for evolving from a trial-and-error approach to a design-driven approach in the development of new functional biomaterials. This progress report critically reviews various strategies developed to decouple the roles of the individual material properties in the biological performance of CaP ceramics. It furthermore emphasizes on the importance of a comprehensive and adequate material characterization that is needed to enhance our knowledge of the property-function relationship of biomaterials used in bone regeneration, and in regenerative medicine in general.
Databáze: OpenAIRE
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