Prostate cancer cell heterogeneity and plasticity: Insights from studies of genetically-engineered mouse models
| Autor: | Michael M. Shen, Weiping Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Cancer Research Cell type Cell of origin Disease Biology Tumor heterogeneity Article 03 medical and health sciences Prostate cancer Mice 0302 clinical medicine Castration Resistance Cancer stem cell medicine Animals Humans Prostate Prostatic Neoplasms medicine.disease Disease Models Animal 030104 developmental biology 030220 oncology & carcinogenesis Genetically Engineered Mouse Cancer research Neoplastic Stem Cells |
| Zdroj: | Semin Cancer Biol |
| ISSN: | 1096-3650 |
| Popis: | Although prostate adenocarcinoma lacks distinguishable histopathological subtypes, prostate cancer displays significant inter- and intratumor heterogeneity at the molecular level and with respect to disease prognosis and treatment response. In principle, understanding the basis for prostate cancer heterogeneity can help distinguish aggressive from indolent disease, and help overcome castration-resistance in advanced prostate cancer. In this review, we will discuss recent advances in understanding the cell types of origin, putative cancer stem cells, and tumor plasticity in prostate cancer, focusing on insights from studies of genetically engineered mouse models (GEMMs). We will also outline future directions for investigating tumor heterogeneity using mouse models of prostate cancer. |
| Databáze: | OpenAIRE |
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