The selective estrogen receptor modulator SCH 57068 prevents bone loss, reduces serum cholesterol and blocks estrogen-induced uterine hypertrophy in ovariectomized rats

Autor: Maria Mendes, Angela M. Cheung, Shangle Qi, Haiqing Hu, Kenneth P.H. Pritzker, Paul E. Goss
Rok vydání: 2004
Předmět:
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Osteoporosis
Blood lipids
Weight Gain
Biochemistry
Bone remodeling
Rats
Sprague-Dawley
chemistry.chemical_compound
Endocrinology
Piperidines
Bone Density
polycyclic compounds
heterocyclic compounds
Femur
Pyridinoline
Lumbar Vertebrae
Molecular Structure
Estrogen Antagonists
Organ Size
Biomechanical Phenomena
Cholesterol
Selective estrogen receptor modulator
Ovariectomized rat
Molecular Medicine
Female
hormones
hormone substitutes
and hormone antagonists
Selective Estrogen Receptor Modulators
medicine.medical_specialty
medicine.drug_class
Ovariectomy
Biology
Article
Internal medicine
medicine
Animals
Molecular Biology
organic chemicals
Uterus
Estrogens
Cell Biology
Hypertrophy
medicine.disease
Rats
carbohydrates (lipids)
Disease Models
Animal
chemistry
Estrogen
Biomarkers
Zdroj: The Journal of steroid biochemistry and molecular biology. 92(1-2)
ISSN: 0960-0760
Popis: Our objective was to determine the effects of SCH 57068 alone and with 17 beta-estradiol (E(2)) on bone, lipids and uteri in ovariectomized (OVX) rats. In OVX animals lumbar vertebral and femoral bone mineral density (BMD) were significantly higher after 12 weeks of treatment with SCH 57068 than in untreated OVX controls. Similarly BMD was superior in OVX + E(2) + SCH 57068 treated animals than in OVX + E(2) controls. SCH 57068 also significantly reduced the increase in bone turnover markers, serum pyridinoline and serum osteocalcin levels, induced by OVX, and increased mechanical bone strength. SCH 57068 also significantly reduced the rise in serum cholesterol and low-density lipoprotein cholesterol induced by OVX. SCH 57068 had no stimulatory effect on uterine epithelium when given alone in OVX rats. SCH 57068 (1 and 2.5 mg/kg) reduced uterine weight and blocked endometrial stimulation induced by E(2). In summary, SCH 57068 adds to the positive effects of E(2) on bone and lipid metabolism but blocks the stimulatory effects of E(2) on the uterus. Potentially, E(2) + SCH 57068 could be combined for the treatment and prevention of breast cancer or as a novel hormone replacement therapy.
Databáze: OpenAIRE
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