Pathological features of bone marrow transplantation-related toxicity in a mouse
| Autor: | Kyoung-Sik Moon, Chang-Su Ha, Moon Koo Chung, Hwa-Young Son, Yong-Hoon Kim, Hyun Sook Lee, Sun Hwa Lim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Pathology Necrosis bone marrow transplantation Spleen Case Report Hemorrhage Thymus Gland Biology Hematocrit Mice Atrophy Bone Marrow Internal medicine Cerebellum Parenchyma Testis medicine Animals Lung Hematology General Veterinary medicine.diagnostic_test pathogenesis Myocardium toxicity medicine.disease Transplantation Mice Inbred C57BL medicine.anatomical_structure Liver histopathology Bone marrow medicine.symptom |
| Zdroj: | Journal of Veterinary Science |
| ISSN: | 1976-555X 1229-845X |
| Popis: | In this case report, we present a mock-transduced bone marrow (BM) transplantation in a mouse, which was found moribund and autopsied to evaluate pathogenesis. Macroscopically, red discoloration of systemic organs was observed. Hematological values revealed a decrease in white blood cells, red blood cells, hematocrit, hemoglobin, and platelets, but an increase in reticulocytes. In BM cytology, hematopoietic cell lines were severely depleted. Histopathologically, hemorrhage in the cerebellar parenchyma, hemosiderin deposition and hemorrhage in the heart, necrosis and telangiectasia in liver, pulmonary parenchymal cysts, spermatogenic germ cells necrosis, atrophy and hemorrhage in testis, oligospermia and hemorrhage in the epididymis, and atrophy of BM, thymus and spleen were observed. In conclusion, autoimmune-like complications such as hematological value change, BM dysplasia and systemic hemorrhage appear to be the lethal cause of the mouse transplanted with mock-transduced BM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|