Effect of Baseline Characteristics on the Pain Response to Pregabalin in Fibromyalgia Patients with Comorbid Depression
| Autor: | Stuart L. Silverman, Miroslav Backonja, Richard Vissing, Pritha Bhadra Brown, Lynne Pauer, Andrew Clair, Jaren W. Landen, Joseph M. Scavone |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Fibromyalgia Adolescent Pregabalin Comorbidity Placebo law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Internal medicine Post-hoc analysis Humans Medicine Psychiatry Irritable bowel syndrome Depression (differential diagnoses) Aged 030203 arthritis & rheumatology Analgesics Cross-Over Studies Depression business.industry General Medicine Middle Aged medicine.disease Crossover study Antidepressive Agents Anesthesiology and Pain Medicine Female Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pain Medicine. 19:419-428 |
| ISSN: | 1526-4637 1526-2375 |
| DOI: | 10.1093/pm/pnx091 |
| Popis: | Objective To evaluate the effect of baseline characteristics on the treatment response to pregabalin in fibromyalgia (FM) patients with depression. Design Post hoc analysis from a randomized, double-blind, placebo-controlled, two-way crossover study of pregabalin (300 or 450 mg/day, twice daily). Subjects A total of 193 FM patients taking an antidepressant for comorbid depression. Methods The effect of patient baseline characteristics on the treatment response to pregabalin vs placebo was assessed for the primary efficacy end point (mean pain score on an 11-point numeric rating scale). Variables were analyzed using a linear mixed effects model with sequence, period, and treatment as fixed factors, and subject within sequence and within subject error as random factors. Results Pregabalin significantly improved mean pain scores vs placebo irrespective of age, duration of FM, number of prior FM medications, depression diagnosis, shorter-term depression ( |
| Databáze: | OpenAIRE |
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