Multiple sites of action of the vitamin D endocrine system: FSH stimulation of testis 1,25-dihydroxyvitamin D3 receptors
| Autor: | Hosea F.S. Huang, Marian R. Walters, Sylvia Christakos, Mary Bitner Anderson, Blake C. Osmundsen |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Receptors Steroid Calcitriol Stimulation Biology Testicle Biochemistry Endocrinology Reference Values Internal medicine Cryptorchidism Testis medicine Endocrine system Animals Receptor Busulfan Hypophysectomy Rats Inbred Strains Sertoli cell Vitamin D Deficiency Rats medicine.anatomical_structure Receptors Calcitriol Follicle Stimulating Hormone Spermatogenesis Germ cell medicine.drug |
| Zdroj: | Journal of steroid biochemistry. 34(1-6) |
| ISSN: | 0022-4731 |
| Popis: | 1,25-Dihydroxyvitamin D [1,25(OH)2D] receptors exist in numerous unexpected tissues. These include, for example, rat lung, heart, testis, and uterus, but not prostate and bladder. The issues of 1,25(OH)2D effects on and receptor location in the testis were addressed by (a) physiological and pharmacological manipulations of tubule cell types and (b) histological examination of testes of vitamin D-deficient rats. FSH treatment in hypophysectomized adult rats increased 1,25(OH)2D receptor levels by 135% (P less than 0.01). Busulfan treatment reduced testis receptor levels by 35% (P less than 0.05) after 35 days (maximum effect), and the effect was reversed after recovery (85 d). Cryptorchidism for 5 or 50 days resulted in modest (33%, P less than 0.05) or substantial (79%, P less than 0.001) reductions in receptor levels. Only the FSH treatment and 50 days cryptorchidism reduced receptor levels in the residual tissue. The testes of vit. D-deficient rats showed incomplete spermatogenesis and degenerative changes. Although interpretation is complicated by the intricate communication among testis cell types, these data suggest that the Sertoli cell is a primary site of action of 1,25(OH)2D in the testis. Moreover, these data indicate that 1,25(OH)2D receptor function in the testis relates to germ cell division/maturation, although this may be an indirect effect via the Sertoli cells. |
| Databáze: | OpenAIRE |
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