Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima - Peru 2001-2013
| Autor: | Juan M Falen, Oswaldo Núñez, María I Rojas, Eliana M Chávez, Martha R Calagua, Miguel A De Los Santos, Carlos Del Águila, Paola M Pinto, Oscar A Espinoza |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Disease 03 medical and health sciences 0302 clinical medicine Endocrinology Langerhans cell histiocytosis Pituitary Hormones Anterior 030225 pediatrics Peru Medicine Humans Desmopressin Child Cerebrum Retrospective Studies Traditional medicine business.industry Brain Neoplasms Significant difference Infant Newborn Infant Retrospective cohort study medicine.disease Prognosis Pathophysiology Histiocytosis Langerhans-Cell Cross-Sectional Studies Child Preschool Pediatrics Perinatology and Child Health Diabetes insipidus Etiology Female business Diabetes Insipidus medicine.drug Follow-Up Studies |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 29(12) |
| ISSN: | 2191-0251 |
| Popis: | Background:Central diabetes insipidus (CDI) is a heterogeneous disease caused by arginine vasopressin deficiency; its management implies a profound understanding of the pathophysiology and the clinical spectrum. The aim of the study was to describe the clinical characteristics that indicate organicity in children and adolescents with central diabetes insipidus treated at the Department of Endocrinology from The Child Health’s Institute during 2001 to 2013.Methods:Cross-sectional, retrospective study. 79 cases of patients diagnosed with CDI (51 males and 28 females) from 1 month to 16 years of age were reviewed. For the descriptive analysis, measures of central tendency and dispersion were used; groups of organic and idiopathic CDI were compared using χResults:The average age of patients was 8.1±4.2 years. Organic causes were intracranial tumors, 44 (55.7%), Langerhans cell histiocytosis (LCH), 11 (13.9%) and cerebral malformations in 7 (8.9%) patients, while the idiopathic group was 14 (17.7%) patients. Regarding clinical characteristics suggestive of organicity, headache (p=0.02) and visual disturbances (p=0.01) were found statistically significant. The anterior pituitary hormonal abnormalities were documented in 34 (52.3%) organic CDI patients. Furthermore, we did not find a significant difference in the average daily dose of desmopressin between patients with permanent vs. transitory CDI (0.81±0.65 vs. 0.59±0.62; p=0.363).Conclusions:The main clinical features suggestive of organicity in pediatric patients with central diabetes insipidus were headache and visual disturbances; furthermore, anterior pituitary hormonal abnormalities suggest an underlying organic etiology. |
| Databáze: | OpenAIRE |
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