High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network
| Autor: | Rossella Zanin, Riccardo Sgarra, Gloria Ros, Daniela D'Angelo, Michela Sgubin, Sabrina Battista, Guidalberto Manfioletti, Silvia Pegoraro, Sara Petrosino |
|---|---|
| Přispěvatelé: | Sgarra, R, Pegoraro, S, D'Angelo, D, Ros, G, Zanin, R, Sgubin, M, Petrosino, S, Battista, S, Manfioletti, G |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
High mobility group A miRNA post-transcriptional regulation cancer [object Object] Computational biology Review Biology Catalysis lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Neoplasms microRNA Gene expression Animals Humans Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Post-transcriptional regulation Gene Spectroscopy HMGA Proteins Organic Chemistry HMGA General Medicine Chromatin Computer Science Applications Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology High-mobility group lcsh:Biology (General) lcsh:QD1-999 030220 oncology & carcinogenesis Cancer cell |
| Zdroj: | International Journal of Molecular Sciences International journal of molecular sciences 21 (2020). doi:10.3390/ijms21030717 info:cnr-pdr/source/autori:Sgarra, Riccardo; Pegoraro, Silvia; D'angelo, Daniela; Ros, Gloria; Zanin, Rossella; Sgubin, Michela; Petrosino, Sara; Battista, Sabrina; Manfioletti, Guidalberto/titolo:High mobility group a (HMGA): Chromatin nodes controlled by a knotty miRNA network/doi:10.3390%2Fijms21030717/rivista:International journal of molecular sciences (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:21 International Journal of Molecular Sciences, Vol 21, Iss 3, p 717 (2020) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21030717 |
| Popis: | High mobility group A (HMGA) proteins are oncofoetal chromatin architectural factors that are widely involved in regulating gene expression. These proteins are unique, because they are highly expressed in embryonic and cancer cells, where they play a relevant role in cell proliferation, stemness, and the acquisition of aggressive tumour traits, i.e., motility, invasiveness, and metastatic properties. The HMGA protein expression levels and activities are controlled by a connected set of events at the transcriptional, post-transcriptional, and post-translational levels. In fact, microRNA (miRNA)-mediated RNA stability is the most-studied mechanism of HMGA protein expression modulation. In this review, we contribute to a comprehensive overview of HMGA-targeting miRNAs; we provide detailed information regarding HMGA gene structural organization and a comprehensive evaluation and description of HMGA-targeting miRNAs, while focusing on those that are widely involved in HMGA regulation; and, we aim to offer insights into HMGA-miRNA mutual cross-talk from a functional and cancer-related perspective, highlighting possible clinical implications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |