Acoustic method for permeability measurement of tissue-engineering scaffold

Autor:	Claudio Guglielmone, Francesco Pennella, Alessandro Schiavi, Umberto Morbiducci
Rok vydání:	2012
Předmět:	Permeability (earth sciences) Transducer Quantitative Biology::Tissues and Organs Applied Mathematics System of measurement Airflow Fluid dynamics Linearity Biological system Instrumentation Engineering (miscellaneous) Tortuosity Effective porosity
Zdroj:	Measurement Science and Technology. 23:105702
ISSN:	1361-6501 0957-0233
DOI:	10.1088/0957-0233/23/10/105702
Popis:	An accurate intrinsic permeability measurement system has been designed and realized in order to quantify the inter-pore connectivity structure of tissue-engineering scaffolds by using a single (pressure) transducer. The proposed method uses a slow alternating airflow as a fluid medium and allows at the same time a simple and accurate measurement procedure. The intrinsic permeability is determined in the linear Darcy's region, and deviation from linearity due to inertial losses is also quantified. The structural parameters of a scaffold, such as effective porosity, tortuosity and effective length of cylindrical pores, are estimated using the classical Ergun's equation recently modified by Wu et al. From this relation, it is possible to achieve a well-defined range of data and associated uncertainties for characterizing the structure/architecture of tissue-engineering scaffolds. This quantitative analysis is of paramount importance in tissue engineering, where scaffold topological features are strongly related to their biological performance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0b7a4161f6f843b1f9bf329f0b448b https://doi.org/10.1088/0957-0233/23/10/105702 Zobrazit plný text záznamu