A risk score system for predicting complicated appendicitis and aid decision-making for antibiotic therapy in acute appendicitis
| Autor: | Peng Zhang, Yuanxin Li, Qian Zhang, Hongwei Zhao, Tianlei Xu, Yiting Meng, Feng Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis medicine.drug_class Antibiotics 030230 surgery Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Antibiotic therapy Humans Medicine Advanced and Specialized Nursing Framingham Risk Score business.industry Area under the curve 030208 emergency & critical care medicine Complicated appendicitis Appendicitis Anti-Bacterial Agents Anesthesiology and Pain Medicine Acute Disease Acute appendicitis Cohort business |
| Zdroj: | Annals of Palliative Medicine. 10:6133-6144 |
| ISSN: | 2224-5839 2224-5820 |
| DOI: | 10.21037/apm-21-26 |
| Popis: | BACKGROUND Exclusive antibiotic therapy is a feasible treatment option for uncomplicated appendicitis, but the pre-treatment diagnosis of uncomplicated appendicitis is challenging. This study aimed to develop a risk score system to predict complicated appendicitis and aiding decision-making regarding antibiotic therapy for acute appendicitis. METHODS The risk score system for predicting complicated appendicitis was constructed and validated by a surgical therapy cohort (n=543). Furthermore, we applied an independent antibiotic treatment cohort (n=169) to verify whether the risk score system could guide antibiotic treatment decision-making in patients with acute appendicitis (AA). RESULTS A total of 543 patients were included in the surgical therapy cohort and was split into the primary (n=375) and validation (n=168) cohorts with repeated random sampling. In the primary cohort, multivariate analysis confirmed that periappendiceal fat stranding (PFS, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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