Evaluation of Electrostatically Endothelial Cell Seeded Expanded Polytetrafluoroethylene Grafts in a Canine Femoral Artery Model
| Autor: | Andrew D. Meyer, Gary L. Bowlin, Anthony D. Cassano, Stanley E. Rittgers, Rick L. Sims, Charles Fields, Raymond G. Makhoul, Jeffrey P. Bulgrin, Cynthia Allen |
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| Rok vydání: | 2002 |
| Předmět: |
Materials science
Endothelium Static Electricity 0206 medical engineering Biomedical Engineering Biocompatible Materials 02 engineering and technology Femoral artery Expanded polytetrafluoroethylene Models Biological Biomaterials Dogs Untreated control medicine.artery Jugular vein medicine Animals Thrombus Polytetrafluoroethylene 021001 nanoscience & nanotechnology medicine.disease 020601 biomedical engineering Blood Vessel Prosthesis Femoral Artery Endothelial stem cell surgical procedures operative medicine.anatomical_structure Microscopy Electron Scanning Seeding Endothelium Vascular 0210 nano-technology Biomedical engineering |
| Zdroj: | Journal of Biomaterials Applications. 17:135-152 |
| ISSN: | 1530-8022 0885-3282 |
| Popis: | (1) Purpose: The purpose of this study was to evaluate the extent (luminal coverage) of the endothelial cell (EC) lining/neointimal development and the thromboresistance of electrostatically EC seeded small diameter e-PTFE vascular grafts. (2) Methods: This evaluation consisted of harvesting autologous, canine jugular vein ECs, electrostatically EC seeding the e-PTFE grafts (4 mm GORE-TEX,® Length = 6 cm), implanting the grafts in a canine femoral artery model for six weeks, and excising the graft for histological and scanning electron microscopy evaluations. (3) Results: The results of the histological evaluation (mid-graft region only) indicated that the electrostatic EC seeding significantly affected neointimal development (p (4) Conclusions: The presence of electrostatic EC seeding significantly (p |
| Databáze: | OpenAIRE |
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