Endogenous facilitation: from molecular mechanisms to persistent pain
| Autor: | Feng Wei, Min Zhuo, Gerald F. Gebhart, Daphne A. Robinson, Amelita A. Calejesan |
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| Rok vydání: | 2005 |
| Předmět: |
Dorsum
Models Neurological Pain Endogeny Inhibitory postsynaptic potential Efferent Pathways Cellular and Molecular Neuroscience Developmental Neuroscience Medicine Animals Feedback Physiological Sensory transmission business.industry Persistent pain Chronic pain Brain Spinal cord medicine.disease medicine.anatomical_structure Neurology Spinal Cord Chronic Disease Facilitation Wounds and Injuries business Neuroscience |
| Zdroj: | Current neurovascular research. 1(1) |
| ISSN: | 1567-2026 |
| Popis: | It is well documented that sensory transmission, including pain, is subject to endogenous inhibitory modulatory influences at dorsal horn of the spinal cord. Recent results, from behavioral to molecular studies, demonstrate that endogenous modulatory systems are bi-phasic, including inhibitory as well as new facilitatory systems. In this review, we propose the existence of endogenous facilitatory systems in the brain, and review evidence supporting the hypothesis. We believe that understanding molecular and cellular mechanisms of endogenous facilitatory systems hold the hope for better future treatment of patients with chronic pain. |
| Databáze: | OpenAIRE |
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