The Energetic Cost of a Night on the Town
| Autor: | Caroline Rae |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Gerontology Magnetic Resonance Spectroscopy Phosphocreatine Energetic cost Energy metabolism Secondary Metabolism Young Adult Physiology (medical) medicine Homeostasis Humans Gray Matter Nucleotides Electroencephalography Middle Aged White Matter Healthy Volunteers Sleep deprivation Editorial Sleep Deprivation Female Neurology (clinical) medicine.symptom Energy Metabolism Sleep Psychology |
| Zdroj: | Sleep. 37:1881-1882 |
| ISSN: | 1550-9109 0161-8105 |
| Popis: | A principal function of sleep may be restoration of brain energy metabolism caused by the energetic demands of wakefulness. Because energetic demands in the brain are greater in gray than white matter, this study used linear mixed-effects models to examine tissue-type specific changes in high-energy phosphates derived using 31P magnetic resonance spectroscopy (MRS) after sleep deprivation and recovery sleep.Experimental laboratory study.Outpatient neuroimaging center at a private psychiatric hospital.A total of 32 MRS scans performed in eight healthy individuals (mean age 35 y; range 23-51 y).Phosphocreatine (PCr) and β-nucleoside triphosphate (NTP) were measured using 31P MRS three dimensional-chemical shift imaging at high field (4 Tesla) after a baseline night of sleep, acute sleep deprivation (SD), and 2 nights of recovery sleep. Novel linear mixed-effects models were constructed using spectral and tissue segmentation data to examine changes in bioenergetics in gray and white matter.PCr increased in gray matter after 2 nights of recovery sleep relative to SD with no significant changes in white matter. Exploratory analyses also demonstrated that increases in PCr were associated with increases in electroencephalographic slow wave activity during recovery sleep. No significant changes in β-NTP were observed.These results demonstrate that sleep deprivation and subsequent recovery-induced changes in high-energy phosphates primarily occur in gray matter, and increases in PCr after recovery sleep may be related to sleep homeostasis. |
| Databáze: | OpenAIRE |
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