Pickled vegetables and the risk of oesophageal cancer: a meta-analysis
| Autor: | Farin Kamangar, Jiansong Ren, Farhad Islami, Philip R. Taylor |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Risk
Cancer Research medicine.medical_specialty oesophageal cancer Esophageal Neoplasms Epidemiology Food Handling pickled vegetable Environmental health Vegetables case–control Medicine Humans Risk factor Prospective cohort study business.industry Case-control study Retrospective cohort study Odds ratio cohort Surgery meta-analysis Oncology Meta-analysis Case-Control Studies business Cohort study |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Ecological and experimental studies have suggested a relationship between Asian pickled vegetable consumption and oesophageal squamous cell carcinoma (OSCC), but the results of epidemiological studies investigating the association have been inconsistent. We conducted a meta-analysis of observational studies of this association to evaluate the existing evidence. Methods: We searched the PubMed, ISI-Web of Science, J-EAST, IndMed, Vip Chinese Periodical, and China National Knowledge Infrastructure databases for all studies published in English or Chinese languages. Pooled results for all studies combined and for several study subgroups were computed. Results: A total of 34 studies were included in this analysis. The overall random effects odds ratio (OR) and 95% confidence interval (CI) for pickled vegetable consumption was 2.08 (1.66–2.60), but the results were heterogeneous across studies. After excluding the three most influential studies, the respective numbers were 2.32 (1.92–2.81). Similar to the overall association, the majority of subgroup analyses showed a statistically significant association between consuming pickled vegetables and OSCC risk. There were only three prospective studies. Conclusion: Our results suggest a potential two-fold increased risk of oesophageal cancer associated with the intake of pickled vegetables. However, because the majority of data was from retrospective studies and there was a high heterogeneity in the results, further well-designed prospective studies are warranted. |
| Databáze: | OpenAIRE |
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