The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention

Autor:	Guo-Ping Ma, Katsushige Ono, Yong-Sheng Liu, Man Yang, Mingqi Zheng, Gang Liu, Le Wang, Ze-Long Cao, Mei Wei
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty China Endocrinology Diabetes and Metabolism medicine.medical_treatment Coronary Artery Disease Thyroid function tests lcsh:Diseases of the endocrine glands. Clinical endocrinology Percutaneous coronary intervention Postoperative Complications Hypothyroidism Risk Factors Subclinical hypothyroidism Diabetes mellitus Internal medicine Cause of Death medicine Humans Mortality Adverse effect Subclinical infection Aged Retrospective Studies Aged 80 and over lcsh:RC648-665 medicine.diagnostic_test business.industry Mortality rate General Medicine medicine.disease Prognosis Older Treatment Outcome nervous system Relative risk Conventional PCI Asymptomatic Diseases Female business Research Article Follow-Up Studies
Zdroj:	BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-9 (2021) BMC Endocrine Disorders
ISSN:	1472-6823
Popis:	Background Subclinical hypothyroidism (SCH) is reportedly associated with an increased risk of adverse events in patients undergoing percutaneous coronary intervention (PCI). The prognostic significance of SCH in the elderly was poorly defined. The purpose of this study was to evaluate the association between SCH and long-term outcomes in older patients undergoing PCI. Methods Three thousand one hundred sixty-eight patients aged 65 years or older who underwent PCI from January 2012 to October 2014 were included. Patients were divided into SCH group (n = 320) and euthyroidism (ET) group (n = 2848) based on thyroid function test. Cox proportional hazard regression analyses were used to estimate the relative risks (RRs) of all-cause death and cardiac death for patients with SCH during a 4-year follow-up period. Results There were 227 deaths during the follow-up period including 124 deaths caused by cardiac events. There was no significant difference in mortality rate between the SCH group and the ET group (p > 0.05). After adjustment for covariates, compared with patients with ET, the RRs of death from all-cause and cardiac in patients with SCH were 1.261 (95%CI: 0.802–1.982, p = 0.315) and 1.231 (95%CI: 0.650–2.334, p = 0.524), respectively. When SCH was stratified by age, gender, and degree of thyroid-stimulating hormone elevation, no significant associations were also found in any stratum. Conclusion Our investigation revealed that SCH was negatively associated with the outcome of PCI in older patients.
Databáze:	OpenAIRE
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